More miles on the clock: neighbourhood stressors are associated with telomere length in a longitudinal study

Ellaway, A. , Dundas, R. , Robertson, T. and Shiels, P. G. (2019) More miles on the clock: neighbourhood stressors are associated with telomere length in a longitudinal study. PLoS ONE, 14(3), e0214380. (doi:10.1371/journal.pone.0214380) (PMID:30921393) (PMCID:PMC6438484)

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Abstract

Background: There is a substantial gap in health and longevity between more affluent and more deprived areas, and more knowledge of the determinants of this health divide is required. Experience of the local residential environment is important for health although few studies have examined this in relation to biological markers of age such as telomere length. We sought to examine if residents’ perceptions of neighbourhood stressors over time were associated with telomere length in a community study. Methodology/Principal findings: In a prospective cohort study of 2186 adults in the West of Scotland, we measured neighbourhood stressors at three time points over a 12-year period and telomere length at the end of the study. Using linear regression models, we found that a higher accumulation of neighbourhood stressors over time was associated with shorter telomere length, even after taking cohort, social class, health behaviours (smoking status, diet, physical activity), BMI and depression into account among females only (Beta = 0.007; 95%CI [0.001, 0.012]; P<0.014). Conclusions/Significance: Neighborhood environments are potentially modifiable, and future efforts directed towards improving deleterious local environments may be useful to lessen telomere attrition.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ellaway, Dr Anne and Shiels, Professor Paul and Dundas, Ms Ruth
Creator Roles:
Ellaway, A.Conceptualization, Formal analysis, Methodology, Writing – original draft
Dundas, R.Formal analysis, Methodology, Writing – review and editing
Shiels, P. G.Conceptualization, Formal analysis, Methodology, Writing – review and editing
Authors: Ellaway, A., Dundas, R., Robertson, T., and Shiels, P. G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > MRC/CSO SPHSU
Journal Name:PLoS ONE
Publisher:Public Library of Science
ISSN:1932-6203
ISSN (Online):1932-6203
Copyright Holders:Copyright © 2019 Ellaway et al.
First Published:First published in PLoS ONE 14(3): e0214380
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
727621SPHSU Core Renewal: Neighbourhoods and Communities Research ProgrammeAnne EllawayMedical Research Council (MRC)MC_UU_12017/10IHW - MRC/CSO SPHU
727651SPHSU Core Renewal: Measuring and Analysing Socioeconomic Inequalities in Health Research ProgrammeAlastair LeylandMedical Research Council (MRC)MC_UU_12017/13IHW - MRC/CSO SPHU
SPSHU10
SPSHU13

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