An unusual case of Erysipelothrix rhusiopathiae prosthetic joint infection from the Canadian Arctic: whole genome sequencing unable to identify a zoonotic source

Groeschel, M., Forde, T. , Turvey, S., Joffe, A. M., Hui, C., Naidu, P., Mavrot, F., Kutz, S. and Singh, A. E. (2019) An unusual case of Erysipelothrix rhusiopathiae prosthetic joint infection from the Canadian Arctic: whole genome sequencing unable to identify a zoonotic source. BMC Infectious Diseases, 19, 282. (doi:10.1186/s12879-019-3913-7) (PMID:30909869)

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Abstract

Background: Erysipelothrix rhusiopathiae is a zoonotic pathogen that causes erysipeloid and is most frequently associated with exposure to domestic swine. Infection of native and prosthetic joints is a rarely reported manifestation. Case presentation: We describe a case of E. rhusiopathiae prosthetic joint infection in a woman with a history of exposure to wild animals in the Canadian Arctic. Patient management involved a 1-stage surgical revision exchange with an antibiotic impregnated cement spacer and 6 weeks of intravenous penicillin G followed by 6 weeks of oral amoxicillin. Ten previously reported cases of E. rhusiopathiae joint infection are reviewed. Recent increases in mortality due to infection with this organism among host animal populations in the Canadian Arctic have generated concern regarding a potential increase in human infections. However, whole genome sequencing (WGS) of the organism was unable to identify a zoonotic origin for this case. Conclusions: Consideration should be given to E. rhusiopathiae as a cause of joint infections if the appropriate epidemiologic and host risk factors exist. Expanded use of WGS in other potential animal hosts and environmental sources may provide important epidemiologic information in determining the source of human infections.

Item Type:Articles
Additional Information:Funding was provided by the National Sciences and Engineering Research Council of Canada Discovery grant to S. Kutz and was used to perform and analyze data for whole genome sequencing of Erysipelothrix isolates.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Forde, Dr Taya
Authors: Groeschel, M., Forde, T., Turvey, S., Joffe, A. M., Hui, C., Naidu, P., Mavrot, F., Kutz, S., and Singh, A. E.
College/School:College of Medical Veterinary and Life Sciences > Institute of Biodiversity Animal Health and Comparative Medicine
Journal Name:BMC Infectious Diseases
Publisher:BioMed Central
ISSN:1471-2334
ISSN (Online):1471-2334
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in BMC Infectious Diseases 19: 282
Publisher Policy:Reproduced under a Creative Commons License

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