Does prior coronary angioplasty affect outcomes of surgical coronary revascularization? Insights from the STICH trial

Nicolau, J. C. et al. (2019) Does prior coronary angioplasty affect outcomes of surgical coronary revascularization? Insights from the STICH trial. International Journal of Cardiology, 291, pp. 36-41. (doi: 10.1016/j.ijcard.2019.03.029) (PMID:30929973)

Abstract

Background: The STICH trial showed superiority of coronary artery bypass plus medical treatment (CABG) over medical treatment alone (MED) in patients with left ventricular ejection fraction (LVEF) ≤35%. In previous publications, percutaneous coronary intervention (PCI) prior to CABG was associated with worse prognosis. Objectives: The main purpose of this study was to analyse if prior PCI influenced outcomes in STICH. Methods and results: Patients in the STICH trial (n = 1212), followed for a median time of 9.8 years, were included in the present analyses. In the total population, 156 had a prior PCI (74 and 82, respectively, in the MED and CABG groups). In those with vs. without prior PCI, the adjusted hazard-ratios (aHRs) were 0.92 (95% CI = 0.74–1.15) for all-cause mortality, 0.85 (95% CI = 0.64–1.11) for CV mortality, and 1.43 (95% CI = 1.15–1.77) for CV hospitalization. In the group randomized to CABG without prior PCI, the aHRs were 0.82 (95% CI = 0.70–0.95) for all-cause mortality, 0.75 (95% CI = 0.62–0.90) for CV mortality and 0.67 (95% CI = 0.56–0.80) for CV hospitalization. In the group randomized to CABG with prior PCI, the aHRs were 0.76 (95% CI = 0.50–1.15) for all-cause mortality, 0.81 (95% CI = 0.49–1.36) for CV mortality and 0.61 (95% CI = 0.41–0.90) for CV hospitalization. There was no evidence of interaction between randomized treatment and prior PCI for any endpoint (all adjusted p > 0.05). Conclusion: In the STICH trial, prior PCI did not affect the outcomes of patients whether they were treated medically or surgically, and the superiority of CABG over MED remained unchanged regardless of prior PCI. Clinical trial registration: Clinicaltrials.gov; Identifier: NCT00023595

• Item Type: Articles
• Additional Information: This work was supported by the National Institutes of Health, National Heart, Lung, and Blood Institute grants U01 HL069015, U01 HL069013, and R01 HL105853.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Petrie, Professor Mark
• Authors: Nicolau, J. C., Stevens, S. R., Al-Khalidi, H. R., Jatene, F. B., Furtado, R. H.M., Dallan, L. A.O., Lisboa, L. A.F., Desvigne-Nickens, P., Haddad, H., Jolicoeur, E. M., Petrie, M. C., Doenst, T., Michler, R. E., Ohman, E. M., Maddury, J., Ali, I., Deja, M. A., Rouleau, J. L., Velazquez, E. J., and Hill, J. A.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: International Journal of Cardiology
• Publisher: Elsevier
• ISSN: 0167-5273
• ISSN (Online): 1874-1754
• Published Online: 15 March 2019
• Copyright Holders: Copyright © 2019 Elsevier B.V.
• First Published: First published in International Journal of Cardiology 291:36-41
• Publisher Policy: Reproduced in accordance with the publisher copyright policy