A novel Hepacivirus in wild rodents from South America

de Souza, W. M., Fumagalli, M. J., Sabino-Santos, G., Motta Maia, F. G., Modha, S. , Teixeira Nunes, M. R., Murcia, P. R. and Moraes Figueiredo, L. T. (2019) A novel Hepacivirus in wild rodents from South America. Viruses, 11(3), e297. (doi: 10.3390/v11030297) (PMID:30909631) (PMCID:PMC6466192)

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The Hepacivirus genus comprises single-stranded positive-sense RNA viruses within the family Flaviviridae. Several hepaciviruses have been identified in different mammals, including multiple rodent species in Africa, Asia, Europe, and North America. To date, no rodent hepacivirus has been identified in the South American continent. Here, we describe an unknown hepacivirus discovered during a metagenomic screen in Akodon montensis, Calomys tener, Oligoryzomys nigripes, Necromys lasiurus, and Mus musculus from São Paulo State, Brazil. Molecular detection of this novel hepacivirus by RT-PCR showed a frequency of 11.11% (2/18) in Oligoryzomys nigripes. This is the first identification of hepavivirus in sigmondonine rodents and in rodents from South America. In sum, our results expand the host range, viral diversity, and geographical distribution of the Hepacivirus genus.

Item Type:Articles
Additional Information:This research was funded by Fundação de Amparo à Pesquisa do Estado de São Paulo, Brazil (Grant number No. 13/14929-1, and Scholarships No. 12/24150-9; 15/05778-5; 17/13981-0; 16/01414-1; 08/06411-4; 11/06810-9; 11/22663-6; 16/02568-2). PRM was supported by the Medical Research Council of the United Kingdom (Grant MC_UU_120/14/9).
Keywords:Viral hepatitis, Hepacivirus, Flaviviridae.
Glasgow Author(s) Enlighten ID:Modha, Ms Sejal and Murcia, Professor Pablo
Authors: de Souza, W. M., Fumagalli, M. J., Sabino-Santos, G., Motta Maia, F. G., Modha, S., Teixeira Nunes, M. R., Murcia, P. R., and Moraes Figueiredo, L. T.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Viruses
ISSN (Online):1999-4915
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Viruses 11:e297
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
709011Quinquennial Core FundsMassimo PalmariniMedical Research Council (MRC)MC_UU_12014/9MVLS III - CENTRE FOR VIRUS RESEARCH