Ischaemic stroke in mice induces lung inflammation but not acute lung injury

Austin, V., Ku, J. M., Miller, A. A. and Vlahos, R. (2019) Ischaemic stroke in mice induces lung inflammation but not acute lung injury. Scientific Reports, 9, 3622. (doi: 10.1038/s41598-019-40392-1) (PMID:30842652) (PMCID:PMC6403328)

Abstract

Stroke is a major cause of death worldwide and ischemic stroke is the most common subtype accounting for approximately 80% of all cases. Pulmonary complications occur in the first few days to weeks following ischemic stroke and are a major contributor to morbidity and mortality. Acute lung injury (ALI) occurs in up to 30% of patients with subarachnoid haemorrhage but the incidence of ALI after ischemic stroke is unclear. As ischemic stroke is the most common subtype of stroke, it is important to understand the development of ALI following the initial ischemic injury to the brain. Therefore, this study investigated whether focal ischemic stroke causes lung inflammation and ALI in mice. Ischemic stroke caused a significant increase in bronchoalveolar lavage fluid (BALF) macrophages and neutrophils and whole lung tissue proinflammatory IL-1β mRNA expression but this did not translate into histologically evident ALI. Thus, it appears that lung inflammation, but not ALI, occurs after experimental ischemic stroke in mice. This has significant implications for organ donors as the lungs from patient's dying of ischemic stroke are not severely damaged and could thus be used for transplantation in people awaiting this life-saving therapy.

• Item Type: Articles
• Additional Information: This study was supported by the National Health and Medical Research Council of Australia [Project Grant ID 1120522].
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Miller, Dr Alyson
• Authors: Austin, V., Ku, J. M., Miller, A. A., and Vlahos, R.
• College/School: College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
• Journal Name: Scientific Reports
• Publisher: Nature Research
• ISSN: 2045-2322
• ISSN (Online): 2045-2322
• Copyright Holders: Copyright © 2019 The Authors
• First Published: First published in Scientific Reports 9(1):3622
• Publisher Policy: Reproduced under a Creative Commons License