ATLANTIS: a randomised multi-arm phase II biomarker-directed umbrella screening trial of maintenance targeted therapy after chemotherapy in patients with advanced or metastatic urothelial cancer

Fulton, B. et al. (2020) ATLANTIS: a randomised multi-arm phase II biomarker-directed umbrella screening trial of maintenance targeted therapy after chemotherapy in patients with advanced or metastatic urothelial cancer. Trials, 21, 344. (doi: 10.1186/s13063-020-04283-5) (PMID:32306987) (PMCID:PMC7168999)

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Abstract

Background: Metastatic urothelial cancer (UC) is the eighth most common cause of cancer death in the UK. Standard first-line treatment, for most patients, is cytotoxic chemotherapy. Although UC is initially sensitive to chemotherapy, relapse is almost inevitable and outcomes are poor; median overall survival is 8 months. Therefore, there is an urgent need for novel therapies to improve outcomes for this patient group. Methods: ATLANTIS is a randomised phase II umbrella-design screening trial of maintenance therapy in biomarker-defined subgroups of patients with advanced UC. The primary end point is progression-free survival, and the study involves over 30 UK cancer centres. Discussion: ATLANTIS is the first study in the UK to employ a precision-medicine approach to patients with UC for maintenance treatment. Agents with a positive efficacy signal will proceed to randomised phase III trials to confirm the activity of novel, biologically stratified therapies in UC. Registration: ATLANTIS trial EudraCT number 2015–003249-25. ISRCTN25859465.

Item Type:Articles
Additional Information:ATLANTIS is jointly funded by Cancer Research UK, Exelixis Inc, Clovis Oncology and Astellas Europe Ltd.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Fulton, Ben and Morris, Miss Anna and Jones, Professor Robert and Soulis, Mrs Eileen
Authors: Fulton, B., Jones, R., Powles, T., Crabb, S., Paul, J., Birtle, A., Chowdhury, S., Hussain, S., Morris, A., Soulis, E., and Morrison, P.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Trials
Publisher:Springer
ISSN:1745-6215
ISSN (Online):1745-6215
Copyright Holders:Copyright © 2020 The Authors
First Published:First published in Trials 21: 344
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
656754ATLANTIS - Maintaining response in Urothelial Cancer: A Personalised Medicine TrialRobert JonesCancer Research UK (CRUK)C24272/A18386RI CANCER SCIENCES