Immune mechanisms of hypertension

Drummond, G. R., Vinh, A., Guzik, T. J. and Sobey, C. G. (2019) Immune mechanisms of hypertension. Nature Reviews Immunology, 19(8), pp. 517-532. (doi: 10.1038/s41577-019-0160-5) (PMID:30992524)

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Abstract

Hypertension affects 30% of adults and is the leading risk factor for heart attack and stroke. Traditionally, hypertension has been regarded as a disorder of two systems that are involved in the regulation of salt–water balance and cardiovascular function: the renin–angiotensin–aldosterone system (RAAS) and the sympathetic nervous system (SNS). However, current treatments that aim to limit the influence of the RAAS or SNS on blood pressure fail in ~40% of cases, which suggests that other mechanisms must be involved. This Review summarizes the clinical and experimental evidence supporting a contribution of immune mechanisms to the development of hypertension. In this context, we highlight the immune cell subsets that are postulated to either promote or protect against hypertension through modulation of cardiac output and/or peripheral vascular resistance. We conclude with an appraisal of knowledge gaps still to be addressed before immunomodulatory therapies might be applied to at least a subset of patients with hypertension.

Item Type:Articles
Additional Information:G.R.D., A.V. and C.G.S. are supported by grants and/or fellow-ships from the National Health and Medical Research Council of Australia (APP1143674, APP1144243 and APP1079467). T.J.G. is supported by a European Research Council Consolidator Grant (726318) and the PLAQUEFIGHT/ERA CVD JTC2017 project.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Guzik, Professor Tomasz
Authors: Drummond, G. R., Vinh, A., Guzik, T. J., and Sobey, C. G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:Nature Reviews Immunology
Publisher:Nature Publishing Group
ISSN:1474-1733
ISSN (Online):1474-1741
Published Online:16 April 2019

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