Ventilation effectiveness in cleanrooms and its relation to decay rate, recovery rate, and air change rate

Whyte, W. , Whyte, W.M., Ward, S. and Agricola, K. (2018) Ventilation effectiveness in cleanrooms and its relation to decay rate, recovery rate, and air change rate. European Journal of Parenteral and Pharmaceutical Sciences, 23(4), pp. 126-134.

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Abstract

Non-unidirectional airflow cleanrooms are supplied with filtered air to minimise the contamination of a product or process by airborne contamination. The effectiveness of the ventilation system in providing the required type of airflow in the cleanroom that will minimise airborne contamination can be assessed by measuring ventilation effectiveness indexes. This article provides information on what ventilation effectiveness indexes are suitable for cleanrooms, and how they can be obtained by test methods in common use in cleanrooms. Three methods of measuring ventilation effectiveness are discussed, namely, the Contamination Removal Effectiveness (CRE) index, the Air Change Effectiveness (ACE) index and the Performance Index (PI), and it was considered that the ACE index and PI were the most suitable for use in cleanrooms. The decay rate and recovery rate of airborne contamination in relation to the air change rate in non-unidirectional cleanrooms is also considered, and it is demonstrated that when measured at the same location, the three rates are identical. Also considered is the measurement of these rates in cleanrooms and how they can be used to obtain the ACE index.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Whyte, Dr William
Authors: Whyte, W., Whyte, W.M., Ward, S., and Agricola, K.
College/School:College of Science and Engineering > School of Engineering
Journal Name:European Journal of Parenteral and Pharmaceutical Sciences
Publisher:Euromed Communications
ISSN:0964-4679
ISSN (Online):0964-4679
Copyright Holders:Copyright © 2018 Pharmaceutical and Healthcare Sciences Society
First Published:First published in European Journal of Parenteral and Pharmaceutical Sciences 23(4):126-134
Publisher Policy:Reproduced with the permission of the publisher
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