TRPM7, magnesium and signaling

Zou, Z.-G., Rios, F. J. , Montezano, A. C. and Touyz, R. M. (2019) TRPM7, magnesium and signaling. International Journal of Molecular Sciences, 20(8), 1877. (doi: 10.3390/ijms20081877) (PMID:30995736) (PMCID:PMC6515203)

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Abstract

The transient receptor potential melastatin-subfamily member 7 (TRPM7) is a ubiquitously expressed chanzyme that possesses an ion channel permeable to the divalent cations Mg2+, Ca2+, and Zn2+, and an α-kinase that phosphorylates downstream substrates. TRPM7 and its homologue TRPM6 have been implicated in a variety of cellular functions and is critically associated with intracellular signaling, including receptor tyrosine kinase (RTK)-mediated pathways. Emerging evidence indicates that growth factors, such as EGF and VEGF, signal through their RTKs, which regulate activity of TRPM6 and TRPM7. TRPM6 is primarily an epithelial-associated channel, while TRPM7 is more ubiquitous. In this review we focus on TRPM7 and its association with growth factors, RTKs, and downstream kinase signaling. We also highlight how interplay between TRPM7, Mg2+ and signaling kinases influences cell function in physiological and pathological conditions, such as cancer and preeclampsia.

Item Type:Articles
Additional Information:Funding: R.M.T. is supported by a British Heart Foundation Award (CH/12/429762). A.C.M. is supported through a Walton Fellowship, University of Glasgow. Z.Z. is funded by China Scholarship Council (201708060309).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Montezano, Dr Augusto and Zou, ZhiGuo and Touyz, Professor Rhian and Rios, Dr Francisco
Authors: Zou, Z.-G., Rios, F. J., Montezano, A. C., and Touyz, R. M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
Journal Name:International Journal of Molecular Sciences
Publisher:MDPI
ISSN:1661-6596
ISSN (Online):1422-0067
Published Online:16 April 2019
Copyright Holders:Copyright © 2019 by the authors
First Published:First published in International Journal of Molecular Sciences 20(8):1877
Publisher Policy:Reproduced under a Creative Commons license

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
3006890Vascular Noxs as therapeutic targets and biomarkers in hypertensionRhian TouyzBritish Heart Foundation (BHF)CH/12/4/29762CAMS - Cardiovascular Science