Methyl donor nutrients in chronic kidney disease: impact on the epigenetic landscape

Mafra, D., Esgalhado, M., Borges, N. A., Cardozo, L. F.M.F., Stockler-Pinto, M. B., Craven, H., Buchanan, S. J., Lindholm, B., Stenvinkel, P. and Shiels, P. G. (2019) Methyl donor nutrients in chronic kidney disease: impact on the epigenetic landscape. Journal of Nutrition, 149(3), pp. 372-380. (doi: 10.1093/jn/nxy289) (PMID:30796783)

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Abstract

Epigenetic alterations, such as those linked to DNA methylation, may potentially provide molecular explanations for complications associated with altered gene expression in illnesses, such as chronic kidney disease (CKD). Although both DNA hypo- and hypermethylation have been observed in the uremic milieu, this remains only a single aspect of the epigenetic landscape and, thus, of any biochemical dysregulation associated with CKD. Nevertheless, the role of uremia-promoting alterations on the epigenetic landscape regulating gene expression is still a novel and scarcely studied field. Although few studies have actually reported alterations of DNA methylation via methyl donor nutrient intake, emerging evidence indicates that nutritional modification of the microbiome can affect one-carbon metabolism and the capacity to methylate the genome in CKD. In this review, we discuss the nutritional modifications that may affect one-carbon metabolism and the possible impact of methyl donor nutrients on the microbiome, CKD, and its phenotype.

Item Type:Articles
Keywords:DNA methylation, chronic kidney disease, epigenetic, genes, methyl donor nutrients.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Buchanan, Dr Sarah and Shiels, Professor Paul and Craven, Hannah
Authors: Mafra, D., Esgalhado, M., Borges, N. A., Cardozo, L. F.M.F., Stockler-Pinto, M. B., Craven, H., Buchanan, S. J., Lindholm, B., Stenvinkel, P., and Shiels, P. G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Journal of Nutrition
Publisher:American Society for Nutrition
ISSN:0022-3166
ISSN (Online):1541-6100
Published Online:23 February 2019

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