Intravital imaging of host-parasite interactions in skin and adipose tissues

De Niz, M., Meehan, G. R. , Brancucci, N. M.B. , Marti, M. , Rotureau, B., Figueiredo, L. M. and Frischknecht, F. (2019) Intravital imaging of host-parasite interactions in skin and adipose tissues. Cellular Microbiology, 21(5), e13023. (doi:10.1111/cmi.13023) (PMID:30825872)

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Abstract

Intravital microscopy (IVM) allows the visualization of how pathogens interact with host cells and tissues in living animals in real time. This method has enabled key advances in our understanding of host-parasite interactions under physiological conditions. A combination of genetics, microscopy techniques and image analysis have recently facilitated the understanding of biological phenomena in living animals at cellular and sub-cellular resolution. In this review, we summarize findings achieved by intravital microscopy of the skin and adipose tissues upon infection with various parasites and we present a view into possible future applications of this method.

Item Type:Articles (Other)
Keywords:Intravital imaging, parasite, adipose skin, plasmodium, trypanosomes toxoplasmosis.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Meehan, Dr Gavin and Marti, Professor Matthias and Brancucci, Dr Nicolas and De Niz, Dr Mariana
Authors: De Niz, M., Meehan, G. R., Brancucci, N. M.B., Marti, M., Rotureau, B., Figueiredo, L. M., and Frischknecht, F.
Subjects:Q Science > QR Microbiology > QR180 Immunology
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Cellular Microbiology
Publisher:Wiley
ISSN:1462-5814
ISSN (Online):1462-5822
Published Online:02 March 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Cellular Microbiology 21(5):e13023
Publisher Policy:Reproduced in accordance with the publisher copyright policy

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
525072Cytoadherence-mediated pathology in cerebral malariaJames BrewerWellcome Trust (WELLCOTR)095507/Z/11/AIII -IMMUNOLOGY