A new computational framework for electro-activation in cardiac mechanics

Garcia-Blanco, E., Ortigosa, R., Gil, A. J., Lee, C. H. and Bonet, J. (2019) A new computational framework for electro-activation in cardiac mechanics. Computer Methods in Applied Mechanics and Engineering, 348, pp. 796-845. (doi: 10.1016/j.cma.2019.01.042)

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This paper presents a novel computational framework for the numerical simulation of the electromechanical response of the myocardium during the cardiac cycle. The paper presents the following main novelties. (1) Two new mixed formulations, tailormade for active stress and active strain coupling approaches, have been developed and used in conjunction with two different ionic models, namely Bueno-Orovio et al. (2008) and Ten Tusscher et al. (2004). Taking as a reference the mixed formulations introduced by Bonet et al. (2015) in the context of nonlinear elasticity, the proposed formulations include as unknown fields the geometry and the transmembrane potential (and possibly a Lagrange multiplier enforcing weakly the incompressibility constraint) as well as the deformation gradient tensor, its cofactor, its determinant, the gradient of the transmembrane potential and their respective work conjugates. The Finite Element implementation of these formulations is shown in this paper, where a static condensation procedure is presented in order to yield an extremely competitive computational approach. (2) A comprehensive and rigorous study of different ionic models (i.e Bueno-Orovio and Ten Tusscher) and electromechanical activation couplings (i.e active strain and active stress) has been carried out. (3) An analytical and numerical analysis of the possible loss of ellipticity and polyconvexity of one of the most widely used constitutive models in the context of cardiac mechanics is carried out in this paper, putting forward possible polyconvexifications of the existing model. (4) In addition, an invariant representation of Guccione’s constitutive model is proposed. Finally, a series of numerical examples are included in order to demonstrate the applicability and robustness of the proposed formulations.

Item Type:Articles
Additional Information:The second and third authors acknowledge the support provided by the Ser Cymru National Research Network ˆ under the Ser Cymru II Fellowship “Virtual engineering of the new generation of biomimetic artificial muscles”, ˆ funded by the European Regional Development Fund. The third author acknowledges the financial support received through the European Training Network AdMoRe (Project ID: 675919).
Glasgow Author(s) Enlighten ID:Lee, Dr Chun Hean
Authors: Garcia-Blanco, E., Ortigosa, R., Gil, A. J., Lee, C. H., and Bonet, J.
College/School:College of Science and Engineering > School of Engineering > Infrastructure and Environment
Journal Name:Computer Methods in Applied Mechanics and Engineering
ISSN (Online):1879-2138
Published Online:12 February 2019
Copyright Holders:Copyright © 2019 Elsevier
First Published:First published in Computer Methods in Applied Mechanics and Engineering 348:796-845
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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