Hijacking the translation apparatus by RNA viruses

Bushell, M. and Sarnow, P. (2002) Hijacking the translation apparatus by RNA viruses. Journal of Cell Biology, 158(3), pp. 395-399. (doi: 10.1083/jcb.200205044) (PMID:12163463) (PMCID:PMC2173839)

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Abstract

As invading viruses do not harbor functional ribosomes in their virions, successful amplification of the viral genomes requires that viral mRNAs compete with cellular mRNAs for the host cell translation apparatus. Several RNA viruses have evolved remarkable strategies to recruit the host translation initiation factors required for the first steps in translation initiation by host cell mRNAs. This review describes the ways that three families of RNA viruses effectively usurp limiting translation initiation factors from the host.

Item Type:Articles
Additional Information:This work was supported by grants from the National Institutes of Health (AI25105 and GM55979) to P. Sarnow, and from The Wellcome Trust (063233/B/00/Z) to M. Bushell.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Bushell, Professor Martin
Authors: Bushell, M., and Sarnow, P.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Journal of Cell Biology
Publisher:Rockefeller University Press
ISSN:0021-9525
ISSN (Online):1540-8140

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