Physical fatigue, fitness, and muscle function in patients with antineutrophil cytoplasmic antibody-associated vasculitis

McClean, A., Morgan, M. D., Basu, N. , Bosch, J. A., Nightingale, P., Jones, D. and Harper, L. (2016) Physical fatigue, fitness, and muscle function in patients with antineutrophil cytoplasmic antibody-associated vasculitis. Arthritis Care and Research, 68(9), pp. 1332-1339. (doi: 10.1002/acr.22827) (PMID:26713864)

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Abstract

Objective: This study investigated differences in cardiorespiratory fitness, muscular function, perceived exertion, and anxiety/depression between patients and healthy controls (HCs) and assessed which of these variables may account for the fatigue experienced by patients. Methods: Fatigue was measured in 48 antineutrophil cytoplasmic antibody–associated vasculitis patients and 41 healthy controls using the Multidimensional Fatigue Inventory (MFI‐20), focusing on the physical component. Quality of life, anxiety/depression, and sleep quality were assessed by validated questionnaires. Muscle mass was measured by dual‐energy x‐ray absorptiometry scan, strength as the maximal voluntary contraction (MVC) force, and endurance as sustained isometric contraction at 50% MVC of the quadriceps. Voluntary activation was assessed by superimposed electrical stimulation. Cardiorespiratory fitness ( urn:x-wiley:00431397:media:acr22827:acr22827-math-0010 and oxygen pulse [O2 pulse]) and perceived exertion (Borg scale) were measured during progressive submaximal exercise. Results: Patients reported elevated physical fatigue scores compared to HCs (patients MFI‐20 physical 13 [interquartile range (IQR) 8–16], HCs MFI‐20 physical 5.5 [IQR 4–8]; P < 0.001). Muscle mass was the same in both groups, but MVC and time to failure in the endurance test were lower due to reduced voluntary activation in patients. Estimated urn:x-wiley:00431397:media:acr22827:acr22827-math-0011 and O2 pulse were the same in both groups. For the same relative workload, patients reported higher ratings of perceived exertion, which correlated with reports of MFI‐20 physical fatigue (R2 = 0.2). Depression (R2 = 0.6), anxiety (R2 = 0.3), and sleep disturbance (R2 = 0.3) were all correlated with MFI‐20 physical fatigue. Conclusion: These observations suggest that fatigue in patients is of a central rather than peripheral origin, supported by associations of fatigue with heightened perception of exertion, depression, anxiety, and sleep disturbance but normal muscle and cardiorespiratory function.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Basu, Professor Neil
Authors: McClean, A., Morgan, M. D., Basu, N., Bosch, J. A., Nightingale, P., Jones, D., and Harper, L.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Arthritis Care and Research
Publisher:Wiley
ISSN:2151-464X
ISSN (Online):2151-4658
Published Online:29 December 2015

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