Chronic inflammation and pancreatic cancer

Mckay, C.J., Glen, P. and McMillan, D.C. (2008) Chronic inflammation and pancreatic cancer. Best Practice and Research: Clinical Gastroenterology, 22(1), pp. 65-73. (doi:10.1016/j.bpg.2007.11.007)

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Abstract

There is a proven association between carcinoma of the pancreas and both the sporadic and hereditary forms of chronic pancreatitis. In chronic pancreatitis the standardised incidence ratio for development of pancreatic cancer is 14–18 and is further increased by cigarette smoking. Underlying mechanisms are unclear but current theories point to the progressive accumulation of genetic mutations as a consequence of repeated DNA damage and cell regeneration in an environment favouring proliferation and neovascularisation. In patients who develop pancreatic cancer, there is interest in the role of the inflammatory response in the development of cancer cachexia and in determining prognosis. Furthermore, markers of a systemic inflammatory response have prognostic significance in both advanced, inoperable pancreatic cancer and in patients undergoing resection. Further understanding of the details of the relationship between inflammation, carcinogenesis and cancer prognosis may lead to new therapeutic possibilities as part of multi-modality management of this difficult disease.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McMillan, Professor Donald
Authors: Mckay, C.J., Glen, P., and McMillan, D.C.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:Best Practice and Research: Clinical Gastroenterology
Publisher:Elsevier
ISSN:1521-6918
ISSN (Online):1532-1916
Published Online:17 January 2008

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