Protocol for a multicentre randomised controlled parallel-group trial to compare the effectiveness of remotely delivered cognitive-behavioural and graded exercise interventions with usual care alone to lessen the impact of fatigue in inflammatory rheumatic diseases (LIFT)

Martin, K. R. et al. (2019) Protocol for a multicentre randomised controlled parallel-group trial to compare the effectiveness of remotely delivered cognitive-behavioural and graded exercise interventions with usual care alone to lessen the impact of fatigue in inflammatory rheumatic diseases (LIFT). BMJ Open, 9(1), e026793. (doi:10.1136/bmjopen-2018-026793) (PMID:30705244)

Martin, K. R. et al. (2019) Protocol for a multicentre randomised controlled parallel-group trial to compare the effectiveness of remotely delivered cognitive-behavioural and graded exercise interventions with usual care alone to lessen the impact of fatigue in inflammatory rheumatic diseases (LIFT). BMJ Open, 9(1), e026793. (doi:10.1136/bmjopen-2018-026793) (PMID:30705244)

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Abstract

Introduction: Fatigue remains pervasive, disabling and challenging to manage across all inflammatory rheumatic diseases (IRDs). Non-pharmacological interventions, specifically cognitive-behavioural approaches (CBAs) and graded exercise programmes designed to support and increase exercise, are valuable treatments which help patients with IRD to manage their fatigue. Yet, healthcare systems have encountered substantial barriers to the implementation of these therapeutic options. Lessening the Impact of Fatigue in Inflammatory Rheumatic Diseases: a Randomised Trial (LIFT) is designed to give insights into the effectiveness of a remotely delivered standardised intervention for a range of patients with IRD. It will also enable the exploration of putative moderating factors which may allow for the future triage of patients and to investigate the precise mediators of treatment effect in IRD-related fatigue. Methods: and analysis LIFT is a pragmatic, multicentre, three-arm randomised, controlled trial, which will test whether adapted CBA and personalised exercise programme interventions can individually reduce the impact and severity of fatigue. This will be conducted with up to 375 eligible patients diagnosed with IRD and interventions will be delivered by rheumatology healthcare professionals, using the telephone or internet-based audio/video calls. Ethics approval and dissemination: Ethical approval has been granted by Wales REC 7 (17/WA/0065). Results of this study will be disseminated through presentation at scientific conferences and in scientific journal. A lay summary of the results will be sent to participants. Trial registration number NCT03248518; Pre-results.

Item Type:Articles
Additional Information:This work was supported by Versus Arthritis (formally known as Arthritis Research UK) grant number 21175. The study is sponsored and led by the University of Aberdeen (King’s College, Aberdeen, AB24 3FX).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Siebert, Dr Stefan and Basu, Dr Neil and Gray, Dr Stuart
Authors: Martin, K. R., Bachmair, E.-M., Aucott, L., Dures, E., Emsley, R., Gray, S. R., Hewlett, S., Kumar, V., Lovell, K., Macfarlane, G. J., MacLennan, G., McNamee, P., Norrie, J., Paul, L., Ralston, S., Siebert, S., Wearden, A., White, P. D., and Basu, N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:BMJ Open
Publisher:BMJ Publishing Group
ISSN:2044-6055
ISSN (Online):2044-6055
Published Online:30 January 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in BMJ Open 9(1):e026793
Publisher Policy:Reproduced under a Creative Commons License

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