Emergence of a three codon deletion in gag p17 in HIV type 1 subtype C long-term survivors, and general population spread

McCormack, G. P., Glynn, J. R., Clewley, J. P., Crampin, A. C. , Travers, S. A.A., Redmond, N., Keane, T. M., Sibande, F., Mulawa, D. and Fine, P. E.M. (2006) Emergence of a three codon deletion in gag p17 in HIV type 1 subtype C long-term survivors, and general population spread. AIDS Research and Human Retroviruses, 22(2), pp. 195-201. (doi: 10.1089/aid.2006.22.195) (PMID:16478403)

Abstract

In a population-based study in northern Malawi we investigated HIV-1 subtype C gag and env gene sequences associated with long-term survival. DNA samples were available from 31 individuals surviving between population surveys carried out in the 1980s and 1990s. Most survivors with paired sequences dating from the 1980s and the 1990s had a three codon deletion in the gag p17 region of the sequence retrieved from the sample collected in the 1990s that was not present in the sequence from the same individual dating from the 1980s. This deletion was also not present in any other 1980s sequences from Malawi, but was common in samples collected in Malawi in the 1990s. The deletion is equivalent to the loss of three amino acids in the D helix region of the gag protein, and may be associated with longer survival and onward transmission.

• Item Type: Articles
• Additional Information: Until 1996 the Karonga Prevention Study was funded primarily by LEPRA (The British Leprosy Relief Association) and ILEP (The International Federation of Anti-Leprosy Organizations) with contributions from the WHO/UNDP/World Bank Special Programme for Research and Training in Tropical Diseases. Since 1996 the Wellcome Trust has been the principalfunder. J.R.G. is funded by the UK Department of Health (Public Health Career Scientist award).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Crampin, Professor Mia
• Authors: McCormack, G. P., Glynn, J. R., Clewley, J. P., Crampin, A. C., Travers, S. A.A., Redmond, N., Keane, T. M., Sibande, F., Mulawa, D., and Fine, P. E.M.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
• Journal Name: AIDS Research and Human Retroviruses
• Publisher: Mary Ann Liebert
• ISSN: 0889-2229
• ISSN (Online): 1931-8405