Bennett, A. A. et al. (2006) The PPD-specific T-cell clonal response in UK and Malawian subjects following BCG vaccination: a new repertoire evolves over 12 months. Vaccine, 24(14), pp. 2617-2626. (doi: 10.1016/j.vaccine.2005.12.011) (PMID:16414159)
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Abstract
Mycobacterium bovis bacille Calmette Guerin vaccination protects against pulmonary tuberculosis in the United Kingdom but not in Malawi. We investigated whether a difference in the clonal T-cell response to BCG vaccination might account for this. The results of clonal analysis were compared to those obtained by skin testing and in a whole blood interferon gamma assay. Pre-vaccination antigen specific T-cell clones were detected, but the majority of clones present 12 months after vaccination were not present earlier. The magnitude of the clonal response did not correlate well with results of the other assays. These data indicate that single assays may not be reliable and that a stable memory T-cell repertoire is slow to develop.
| Item Type: | Articles |
|---|---|
| Additional Information: | This work was supported by the Edward Jenner Institute for Vaccine Research and The Wellcome Trust. |
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Crampin, Professor Mia |
| Authors: | Bennett, A. A., Gorak-Stolinska, P., Ben-Smith, A., Floyd, S., de Lara, C. M., Weir, R. E., Lalor, M. K., Makamo, K., Msiska, G. K., Crampin, A. C., Fine, P. E.M., Dockrell, H. M., and Beverley, P. C.L. |
| College/School: | College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health |
| Journal Name: | Vaccine |
| Publisher: | Elsevier |
| ISSN: | 0264-410X |
| ISSN (Online): | 1873-2518 |
| Published Online: | 27 December 2005 |
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