Population differences in immune responses to Bacille Calmette‐Guérin vaccination in infancy

Lalor, M. K. et al. (2009) Population differences in immune responses to Bacille Calmette‐Guérin vaccination in infancy. Journal of Infectious Diseases, 199(6), pp. 795-800. (doi: 10.1086/597069) (PMID:19434928) (PMCID:PMC3276835)

Abstract

Bacille Calmette-Guérin (BCG) vaccination induces a marked increase in the interferon (IFN)–γ response to Mycobacterium tuberculosis purified protein derivative (Mtb PPD) in UK adolescents, but not in Malawian adolescents. We hypothesized that Mtb PPD-induced IFN-γ after BCG vaccination would be similar in infants from these 2 countries. Infants were vaccinated with BCG during the first 3–13 weeks of life. Three months after BCG vaccination, 51 (100%) of 51 UK infants had an IFN-γ response to Mtb PPD, compared to 41 (53%) of 78 of Malawian infants, in whom responses varied according to their season of birth. We conclude that population differences in immune responses after BCG vaccination are observed among infants, as well as among young adults.

• Item Type: Articles
• Additional Information: Financial support: Wellcome Trust (grant number 063558/Z/01/B to P.E.M.F., H.M.D., and B. Zaba); Bill and Melinda Gates Foundation Grand Challenge (award 6_74 to S.H.E. Kaufmann, principal investigator; H.M.D., coinvestigator).
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Crampin, Professor Mia
• Authors: Lalor, M. K., Ben‐Smith, A., Gorak‐Stolinska, P., Weir, R. E., Floyd, S., Blitz, R., Mvula, H., Newport, M. J., Branson, K., McGrath, N., Crampin, A. C., Fine, P. E.M., and Dockrell, H. M.
• College/School: College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
• Journal Name: Journal of Infectious Diseases
• Publisher: Oxford University Press
• ISSN: 0022-1899
• ISSN (Online): 1537-6613
• Published Online: 02 February 2009