Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2

Thye, T. et al. (2010) Genome-wide association analyses identifies a susceptibility locus for tuberculosis on chromosome 18q11.2. Nature Genetics, 42(9), pp. 739-741. (doi: 10.1038/ng.639) (PMID:20694014) (PMCID:PMC4975513)

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Abstract

We combined two tuberculosis genome-wide association studies from Ghana and The Gambia with subsequent replication in a combined 11,425 individuals. rs4331426, located in a gene-poor region on chromosome 18q11.2, was associated with disease (combined P = 6.8 × 10−9, odds ratio = 1.19, 95% CI = 1.13–1.27). Our study demonstrates that genome-wide association studies can identify new susceptibility loci for infectious diseases, even in African populations, in which levels of linkage disequilibrium are particularly low.

Item Type:Articles
Additional Information:Authors, for the African TB Genetics Consortium and the Wellcome Trust Case Control Consortium.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Crampin, Professor Mia
Authors: Thye, T., Vannberg, F. O., Wong, S. H., Owusu-Dabo, E., Osei, I., Gyapong, J., Sirugo, G., Sisay-Joof, F., Enimil, A., Chinbuah, M. A., Floyd, S., Warndorff, D. K., Sichali, L., Malema, S., Crampin, A. C., Ngwira, B., Teo, Y. Y., Small, K., Rockett, K., Kwiatkowski, D., Fine, P. E., Hill, P. C., Newport, M., Lienhardt, C., Adegbola, R. A., Corrah, T., Ziegler, A., Morris, A. P., Meyer, C. G., Horstmann, R. D., and Hill, A. V.S.
College/School:College of Medical Veterinary and Life Sciences > School of Health & Wellbeing > Public Health
Journal Name:Nature Genetics
Publisher:Nature Research
ISSN:1061-4036
ISSN (Online):1546-1718

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