A review of the application of hollow-fiber liquid-phase microextraction in bioanalytical methods - a systematic approach with focus on forensic toxicology

Venson, R. , Korb, A.-S. and Cooper, G. (2019) A review of the application of hollow-fiber liquid-phase microextraction in bioanalytical methods - a systematic approach with focus on forensic toxicology. Journal of Chromatography B, 1108, pp. 32-53. (doi: 10.1016/j.jchromb.2019.01.006) (PMID:30682538)

179678.pdf - Accepted Version
Available under License Creative Commons Attribution Non-commercial No Derivatives.



Over the past three decades, many studies employing hollow-fiber liquid-phase microextraction (HF-LPME) bioanalytical methods have been published. The basic mechanism of extraction relies on the migration of the analytes through a liquid membrane sustained in the pores of the walls of a porous hollow fiber, and from there into an acceptor phase present in the lumen of the fiber. The mass transfer occurs by passive diffusion and it can be enhanced by using a carrier or applying an electrical potential across the phases. This type of extraction method presents many advantages over classical techniques, such as high preconcentration factor, clean extracts, and a green chemistry approach. Due to its advantages, and considering that no study systematically compiled the characteristics of the published methods in one single accessible source of information, the aim of this systematic review is to assess the data regarding bioanalytical methods, compile, and analyse the studies published until up to October of 2017. The data source used for the systematic review were Pubmed, Web of Science, and Science Direct, and 171 studies were included in the final review by two independent reviewers, resulting in a reliable and accessible source of information about bioanalytical methods employing HF-LPME.

Item Type:Articles
Additional Information:This work was supported by CAPES (Coordenação de Aperfeiçoamento de Pessoal de Nivel Superior - Sciences without Boarders) [grant number 18658-12-1].
Keywords:Bioanalysis, forensic toxicology, green chemistry, hollow-fiber liquid-phase microextraction, sample preparation.
Glasgow Author(s) Enlighten ID:Korb, Dr Ann-Sophie and Cooper, Dr Gail and Venson, Dr Rafael
Authors: Venson, R., Korb, A.-S., and Cooper, G.
College/School:College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Health Economics and Health Technology Assessment
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Journal of Chromatography B
ISSN (Online):1873-376X
Published Online:17 January 2019
Copyright Holders:Copyright © 2019 Elsevier B.V.
First Published:First published in Journal of Chromatography B 1108: 32-53
Publisher Policy:Reproduced in accordance with the publisher copyright policy

University Staff: Request a correction | Enlighten Editors: Update this record