AKAP95 organizes a nuclear microdomain to control local cAMP for regulating nuclear PKA

Clister, T., Greenwald, E. C., Baillie, G. S. and Zhang, J. (2019) AKAP95 organizes a nuclear microdomain to control local cAMP for regulating nuclear PKA. Cell Chemical Biology, 26(6), pp. 885-891. (doi: 10.1016/j.chembiol.2019.03.003) (PMID:30982750)

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Abstract

Contrary to the classic model of protein kinase A (PKA) residing outside of the nucleus, we identify a nuclear signaling complex that consists of AKAP95, PKA, and PDE4D5 and show that it forms a functional cyclic AMP (cAMP) signaling microdomain. Locally generated cAMP can accumulate within the vicinity of this complex; however, when cAMP is generated at the plasma membrane, PDE4 serves as a local sink and PDE3 as a barrier to prevent accumulation of cAMP within the microdomain as a means of controlling activation of tethered nuclear PKA.

Item Type:Articles
Additional Information:This work was funded by NIH, R01 DK073368 (to J.Z.) and F32 GM120798-02 (to E.G.).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Baillie, Professor George
Authors: Clister, T., Greenwald, E. C., Baillie, G. S., and Zhang, J.
College/School:College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health
Journal Name:Cell Chemical Biology
Publisher:Elsevier (Cell Press)
ISSN:2451-9456
ISSN (Online):2451-9448
Published Online:11 April 2019
Copyright Holders:Copyright © 2019 Elsevier Ltd.
First Published:First published in Cell Chemical Biology 26(6):885-891
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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