Clister, T., Greenwald, E. C., Baillie, G. S. and Zhang, J. (2019) AKAP95 organizes a nuclear microdomain to control local cAMP for regulating nuclear PKA. Cell Chemical Biology, 26(6), pp. 885-891. (doi: 10.1016/j.chembiol.2019.03.003) (PMID:30982750)
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Abstract
Contrary to the classic model of protein kinase A (PKA) residing outside of the nucleus, we identify a nuclear signaling complex that consists of AKAP95, PKA, and PDE4D5 and show that it forms a functional cyclic AMP (cAMP) signaling microdomain. Locally generated cAMP can accumulate within the vicinity of this complex; however, when cAMP is generated at the plasma membrane, PDE4 serves as a local sink and PDE3 as a barrier to prevent accumulation of cAMP within the microdomain as a means of controlling activation of tethered nuclear PKA.
Item Type: | Articles |
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Additional Information: | This work was funded by NIH, R01 DK073368 (to J.Z.) and F32 GM120798-02 (to E.G.). |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Baillie, Professor George |
Authors: | Clister, T., Greenwald, E. C., Baillie, G. S., and Zhang, J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cardiovascular & Metabolic Health |
Journal Name: | Cell Chemical Biology |
Publisher: | Elsevier (Cell Press) |
ISSN: | 2451-9456 |
ISSN (Online): | 2451-9448 |
Published Online: | 11 April 2019 |
Copyright Holders: | Copyright © 2019 Elsevier Ltd. |
First Published: | First published in Cell Chemical Biology 26(6):885-891 |
Publisher Policy: | Reproduced in accordance with the copyright policy of the publisher |
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