Measuring the Effects of Listening for Leisure on Outcome after stroke (MELLO): a pilot randomised controlled trial of mindful music listening

Baylan, S. et al. (2019) Measuring the Effects of Listening for Leisure on Outcome after stroke (MELLO): a pilot randomised controlled trial of mindful music listening. International Journal of Stroke, (doi:10.1177/1747493019841250) (PMID:30940047) (Early Online Publication)

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Abstract

Background: Cognitive deficits and low mood are common post-stroke. Music listening is suggested to have beneficial effects on cognition, while mindfulness may improve mood. Combining these approaches may enhance cognitive recovery and improve mood early post-stroke. Aims: To assess the feasibility and acceptability of a novel mindful music listening intervention. Methods: A parallel group randomized controlled feasibility trial with ischemic stroke patients, comparing three groups; mindful music listening, music listening and audiobook listening (control group), eight weeks intervention. Feasibility was measured using adherence to protocol and questionnaires. Cognition (including measures of verbal memory and attention) and mood (Hospital Anxiety and Depression Scale) were assessed at baseline, end of intervention and at six-months post-stroke. Results: Seventy-two participants were randomized to mindful music listening (n = 23), music listening (n = 24), or audiobook listening (n = 25). Feasibility and acceptability measures were encouraging: 94% fully consistent with protocol; 68.1% completing ≥6/8 treatment visits; 80–107% listening adherence; 83% retention to six-month endpoint. Treatment effect sizes for cognition at six month follow-up ranged from d = 0.00 ([−0.64,0.64], music alone), d = 0.31, ([0.36,0.97], mindful music) for list learning; to d = 0.58 ([0.06,1.11], music alone), d = 0.51 ([−0.07,1.09], mindful music) for immediate story recall; and d = 0.67 ([0.12,1.22], music alone), d = 0.77 ([0.16,1.38]mindful music) for attentional switching compared to audiobooks. No signal of change was seen for mood. A definitive study would require 306 participants to detect a clinically substantial difference in improvement (z-score difference = 0.66, p = 0.017, 80% power) in verbal memory (delayed story recall). Conclusions: Mindful music listening is feasible and acceptable post-stroke. Music listening interventions appear to be a promising approach to improving recovery from stroke.

Item Type:Articles
Keywords:Mindfulness, music, mood, cognition, rehabilitation, stroke, ischaemic, audiobooks.
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Easto, Mr Jake and Thomson, Meigan and Mercer, Professor Stewart and Evans, Professor Jonathan and Cullen, Dr Breda and Stiles, Ms Ciara and Murray, Mrs Heather and Broomfield, Dr Niall and MacDonald, Miss Maxine and Baylan, Dr Satu and Stott J, Professor David and Quinn, Dr Terry and Haig, Dr Caroline
Authors: Baylan, S., Haig, C., MacDonald, M., Stiles, C., Easto, J., Thomson, M., Cullen, B., Quinn, T. J., Stott, D. J., Mercer, S. W., Broomfield, N. M., Murray, H., and Evans, J. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > General Practice and Primary Care
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Mental Health and Wellbeing
College of Medical Veterinary and Life Sciences > Institute of Health and Wellbeing > Robertson Centre
Journal Name:International Journal of Stroke
Publisher:SAGE
ISSN:1747-4930
ISSN (Online):1747-4949
Published Online:02 April 2019
Copyright Holders:Copyright © 2019 World Stroke Organization
First Published:First published in International Journal of Stroke 2019
Publisher Policy:Reproduced under a Creative Commons License

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