Allan, G. J., Inman, G. J. , Parker, B. D., Rowe, D. T. and Farrell, P. J. (1992) Cell growth effects of Epstein-Barr virus leader protein. Journal of General Virology, 73(6), pp. 1547-1551. (doi: 10.1099/0022-1317-73-6-1547) (PMID:1318948)
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Abstract
B lymphoblastoid cell lines immortalized with P3HR1/633 Epstein—Barr virus (EBV), which has a deletion in the EBV nuclear antigen leader protein (EBNA-LP) gene, were transfected with a vector expressing wild-type EBNA-LP. The EBNA-LP trans-fectants grew out faster under G418 selection than control cells but expression of EBNA-LP made no significant difference to growth rate or saturation density of the resulting established cell lines. When the cells expressing EBNA-LP were allowed to grow to saturation and then diluted in fresh medium they underwent DNA synthesis more rapidly than control cultures.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Inman, Professor Gareth |
Authors: | Allan, G. J., Inman, G. J., Parker, B. D., Rowe, D. T., and Farrell, P. J. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences |
Journal Name: | Journal of General Virology |
Publisher: | Microbiology Society |
ISSN: | 0022-1317 |
ISSN (Online): | 1465-2099 |
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