Human papillomaviruses, tumour suppressor genes and cervical cancer

Inman, G.J. , Cook, I.D. and Lau, R.K.W. (1993) Human papillomaviruses, tumour suppressor genes and cervical cancer. International Journal of STD and AIDS, 4(3), pp. 128-134. (doi:10.1177/095646249300400302) (PMID:8391853)

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Abstract

There is now a considerable body of evidence that links HPV infection with anogenital squamous carcinoma, particularly for specific ‘high risk’ HPV types (HPV16 and 18) and invasive carcinoma of the cervix. Recent advances in the molecular study of these viruses have elucidated some potential mechanisms by which they may contribute to the development of these diseases. In this review we concentrate on the interactions of 2 of the HPV encoded proteins, E6 and E7, with cellular tumour suppressor gene products. We provide a model of how these interactions may be important in tumourigenesis and draw together current knowledge of this exciting and rapidly evolving field.

Item Type:Articles (Editorial)
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Inman, Professor Gareth
Authors: Inman, G.J., Cook, I.D., and Lau, R.K.W.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:International Journal of STD and AIDS
Publisher:SAGE
ISSN:0956-4624
ISSN (Online):1758-1052

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