Genetic influence of cytokine polymorphisms on the clinical outcome of Japanese gastrointestinal cancer patients in palliative care

Hishida, A. et al. (2018) Genetic influence of cytokine polymorphisms on the clinical outcome of Japanese gastrointestinal cancer patients in palliative care. Oncology Letters, 17(1), pp. 623-629. (doi:10.3892/ol.2018.9614) (PMID:30655809) (PMCID:PMC6313183)

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Abstract

Gastrointestinal cancer is one of the most common causes of mortality globally. The present study examined the influence of cytokine genetic polymorphisms [interleukin ( C-31T, VNTR, C-634G, T-251A, T-819C and A-1082G] on clinical outcomes in patients with gastrointestinal cancer in palliative care. A total of 59 patients with gastrointestinal cancer who were admitted to Iga City General Hospital were analyzed. Genotyping was conducted using a polymerase chain reaction with confronting two-pair primers. Patients with at least one allele demonstrated a significantly better survival (P=0.0275) while those with -634 demonstrated a worse survival (P=0.0024). Multivariate analyses using the Cox proportional hazard model revealed that those with at least one allele, -634 or -1082 had a significantly elevated adjusted hazard ratio of 9.20 (P=0.014), 41.01 (P=0.001) or 6.49 (P=0.046), respectively, compared with those with each homozygous wild-type polymorphism. In addition, the evaluation of weight loss by genotype revealed the potential influence of T-819C genotype (P=0.072). and polymorphisms were associated with the survival of patients with gastrointestinal cancer, suggesting the clinical feasibility of genetic testing in patients with gastrointestinal cancer in palliative care.

Item Type:Articles
Additional Information:The present study was supported in part by Grants-in-Aid for Scientific Research from the Japanese Ministry of Education, Culture, Sports, Science and Technology, JSPS KAKENHI Grant Number JP (grant no. 25460745).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McMillan, Professor Donald
Authors: Hishida, A., Okugawa, Y., Morimoto, Y., Shirai, Y., Okamoto, K., Momokita, S., Ogawa, A., Tanaka, K., Nishikawa, R., Toiyama, Y., Inoue, Y., Sakurai, H., Urata, H., Tanaka, M., McMillan, D. C., and Miki, C.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:Oncology Letters
ISSN:1792-1074
ISSN (Online):1792-1082

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