Persistent endothelial activation and inflammation after Plasmodium falciparum infection in Malawian children

Moxon, C. A. et al. (2014) Persistent endothelial activation and inflammation after Plasmodium falciparum infection in Malawian children. Journal of Infectious Diseases, 209(4), pp. 610-615. (doi: 10.1093/infdis/jit419) (PMID:24048963) (PMCID:PMC3903368)

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Abstract

Endothelial dysregulation is central to the pathogenesis of acute Plasmodium falciparum infection. It has been assumed that this dysregulation resolves rapidly after treatment, but this return to normality has been neither demonstrated nor quantified. We therefore measured a panel of plasma endothelial markers acutely and in convalescence in Malawian children with uncomplicated or cerebral malaria. Evidence of persistent endothelial activation and inflammation, indicated by increased plasma levels of soluble intracellular adhesion molecule 1, angiopoetin 2, and C-reactive protein, were observed at 1 month follow-up visits. These vascular changes may represent a previously unrecognized contributor to ongoing malaria-associated morbidity and mortality.

Item Type:Articles
Additional Information:This work was supported by a Clinical PhD Fellowship from The Wellcome Trust, United Kingdom (88758 to C. A. M.); and by a grant from the NIH (5R01AI034969-14 to T. E. T.). The Malawi-Liverpool-Wellcome Clinical Research Programme is supported by core funding from The Wellcome Trust.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Seydel, Dr Karl and Moxon, Dr Christopher
Authors: Moxon, C. A., Chisala, N. V., Wassmer, S. C., Taylor, T. E., Seydel, K. B., Molyneux, M. E., Faragher, B., Kennedy, N., Toh, C.-H., Craig, A. G., and Heyderman, R. S.
College/School:College of Medical Veterinary and Life Sciences > School of Infection & Immunity
Journal Name:Journal of Infectious Diseases
Publisher:Oxford University Press
ISSN:0022-1899
ISSN (Online):1537-6613
Published Online:17 September 2013
Copyright Holders:Copyright © 2013 The Authors
First Published:First published in Journal of Infectious Diseases 209(4): 610-615
Publisher Policy:Reproduced under a Creative Commons License

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