Moxon, C. A. et al. (2014) Persistent endothelial activation and inflammation after Plasmodium falciparum infection in Malawian children. Journal of Infectious Diseases, 209(4), pp. 610-615. (doi: 10.1093/infdis/jit419) (PMID:24048963) (PMCID:PMC3903368)
|
Text
179120.pdf - Published Version Available under License Creative Commons Attribution. 356kB |
Abstract
Endothelial dysregulation is central to the pathogenesis of acute Plasmodium falciparum infection. It has been assumed that this dysregulation resolves rapidly after treatment, but this return to normality has been neither demonstrated nor quantified. We therefore measured a panel of plasma endothelial markers acutely and in convalescence in Malawian children with uncomplicated or cerebral malaria. Evidence of persistent endothelial activation and inflammation, indicated by increased plasma levels of soluble intracellular adhesion molecule 1, angiopoetin 2, and C-reactive protein, were observed at 1 month follow-up visits. These vascular changes may represent a previously unrecognized contributor to ongoing malaria-associated morbidity and mortality.
Item Type: | Articles |
---|---|
Additional Information: | This work was supported by a Clinical PhD Fellowship from The Wellcome Trust, United Kingdom (88758 to C. A. M.); and by a grant from the NIH (5R01AI034969-14 to T. E. T.). The Malawi-Liverpool-Wellcome Clinical Research Programme is supported by core funding from The Wellcome Trust. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Seydel, Dr Karl and Moxon, Dr Christopher |
Authors: | Moxon, C. A., Chisala, N. V., Wassmer, S. C., Taylor, T. E., Seydel, K. B., Molyneux, M. E., Faragher, B., Kennedy, N., Toh, C.-H., Craig, A. G., and Heyderman, R. S. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Journal of Infectious Diseases |
Publisher: | Oxford University Press |
ISSN: | 0022-1899 |
ISSN (Online): | 1537-6613 |
Published Online: | 17 September 2013 |
Copyright Holders: | Copyright © 2013 The Authors |
First Published: | First published in Journal of Infectious Diseases 209(4): 610-615 |
Publisher Policy: | Reproduced under a Creative Commons License |
University Staff: Request a correction | Enlighten Editors: Update this record