iASPP inhibition: Increased options in targeting the p53 family for cancer therapy

Bell, H. and Ryan, K. (2008) iASPP inhibition: Increased options in targeting the p53 family for cancer therapy. Cancer Research, 68(13), pp. 4959-4962. (doi:10.1158/0008-5472.CAN-08-0182)

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Abstract

Strategies to induce p53 for cancer therapy offer appeal but many tumors harbor inactivating p53 mutations. One way to address this situation may be to activate the p53-related protein p73, which functions similarly, but unlike p53, is rarely lost or mutated in cancer. Along these lines, a recent study reports that a p53-derived peptide that targets iASPP-a common negative regulator of p53 family members-can effectively trigger tumor cell death by a p73-dependent mechanism. These findings promote further study of iASPP targeting as a therapeutic strategy to activate p73

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ryan, Professor Kevin
Authors: Bell, H., and Ryan, K.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
Journal Name:Cancer Research
ISSN:0008-5472

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