Senescent cells in early vascular ageing and bone disease of chronic kidney disease—a novel target for treatment

Hobson, S., Arefin, S., Kublickiene, K., Shiels, P. G. and Stenvinkel, P. (2019) Senescent cells in early vascular ageing and bone disease of chronic kidney disease—a novel target for treatment. Toxins, 11(2), 82. (doi: 10.3390/toxins11020082) (PMID:30717151) (PMCID:PMC6409791)

Abstract

Together with bone-mineral disorders, premature vascular ageing is a common feature of the uremic phenotype. A detailed understanding of mechanisms involved remains unclear and warrants further research. Available treatment options for end stage renal disease are principally dialysis and organ transplantation, as other treatment alternatives have proven insufficient. Chronic kidney disease (CKD) has been proposed as a model of early vascular and bone ageing, with accumulating evidence supporting the contribution of cellular senescence and the senescence-associated secretory phenotype (SASP) to cardiovascular pathology in CKD. Correspondingly, novel therapies based around the use of senolytic compounds and nuclear factor-erythroid-2-related factor 2 (Nrf2) agonists, have been suggested as attractive novel treatment options. In this review, we detail the contribution of the uremic environment to these processes underpinning ageing and how these relate to vascular health.

• Item Type: Articles
• Additional Information: This project has received funding from the European Union’s Horizon 2020 research and innovation program under grant agreement no. 764474.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Shiels, Professor Paul
• Authors: Hobson, S., Arefin, S., Kublickiene, K., Shiels, P. G., and Stenvinkel, P.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Toxins
• Publisher: MDPI
• ISSN: 2072-6651
• ISSN (Online): 2072-6651
• Published Online: 01 February 2019
• Copyright Holders: Copyright © 2019 The Authors
• First Published: First published in Toxins 11(2): 82
• Publisher Policy: Reproduced under a Creative Commons License