In vitro Hemocompatibility Assessment of Near-IR-Emitting Ag2S Quantum Dots (QD)

Grandfils, C., Hocaoglu, I., Demir, F. , Birer, O., Kiraz, A., Sevrin, C. and Yagci Acar, H. (2014) In vitro Hemocompatibility Assessment of Near-IR-Emitting Ag2S Quantum Dots (QD). Nanobiotechnology International Workshop, Ispra, Italy, 24-26 Nov 2014.

Abstract

Quantum Dots (QDs) emitting in the Near-Infrared region (NIRQD) are relatively new but more attractive in biotechnology and medicine, than widely used visible QDs. However, heavy metal toxicity is an important concern for their parenteral applications. Recent efforts have been directed towards development of Cd, Pb and Hg free, biocompatible QDs. Hocaoglu et al. have recently demonstrated a single-step synthesis of cytocompatible Ag2S-2MPA NIRQDs via direct addition of sulphur source to silver salt 1. Till now, very few studies have assessed the hemocompatibility of QDs. Indeed, when diluted in the blood stream nanomaterials will be able to elicit several toxicological reactions, in particular: embolisation, hemolysis, cellular activation, but also several well-known biological cascades such as coagulation, complement activation, kinin/kininogen, fibrinolysis. Compared to macroscopic materials, hemoreactivity of nanoparticles may be expected to be significantly enhanced due to very high surface/volume ratio. It is therefore easy to realize that nanoparticles may significantly interact with humoral and cellular blood components of the blood 2.

• Item Type: Conference or Workshop Item
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Demir Duman, Dr Fatma
• Authors: Grandfils, C., Hocaoglu, I., Demir, F., Birer, O., Kiraz, A., Sevrin, C., and Yagci Acar, H.
• Subjects: Q Science > QD Chemistry
• College/School: College of Science and Engineering > School of Chemistry