Naz Guven, M., Akyol, E., Demir Duman, F. , Yagci Acar, H., Karahan, O. and Avci, D. (2017) Urea dimethacrylates functionalized with bisphosphonate/bisphosphonic acid for improved dental materials. Journal of Polymer Science Part A: Polymer Chemistry, 55(19), pp. 3195-3204. (doi: 10.1002/pola.28684)
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Abstract
Incorporation of bisphosphonate/bisphosphonic acid groups in dental monomer structures should increase interaction of these monomers with dental tissue as these groups have strong affinity for hydroxyapatite. Therefore, new urea dimethacrylates functionalized with bisphosphonate (1a, 1b) and bisphosphonic acid (2a, 2b) groups are synthesized and evaluated for dental applications. Monomers 1a and 1b are synthesized from 2‐isocyanatoethyl methacrylate (IEM) and two bisphosphonated amines (BPA1 and BPA2), prepared as reported elsewhere. Selective dealkylation of the bisphosphonate ester groups of 1a and 1b using trimethylsilyl bromide (TMSBr) gives monomers (2a and 2b) with bisphosphonic acid functionality. X‐ray diffractometer (XRD), Raman spectroscopy, and X‐ray photoelectron spectroscopy (XPS) analyses of monomer‐treated HAP particles show that 2a induces formation of stable monomer‐calcium salts, similar to 10‐methacryloyloxydecyl dihydrogen phosphate (MDP), with higher chemical interaction than 2b. The photopolymerization studies indicate good copolymerizability with commercial dental monomers. In vitro studies on NIH 3T3 mouse embryonic fibroblast cells have clearly shown that the tested monomers (1b and 2b) are not toxic according to the MTT standards. All these properties make these monomers suitable as biocompatible cross‐linkers/adhesives for dental applications.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Demir Duman, Dr Fatma |
| Authors: | Naz Guven, M., Akyol, E., Demir Duman, F., Yagci Acar, H., Karahan, O., and Avci, D. |
| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Journal of Polymer Science Part A: Polymer Chemistry |
| Publisher: | Wiley |
| ISSN: | 0887-624X |
| ISSN (Online): | 1099-0518 |
| Published Online: | 06 July 2017 |
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