Demir Duman, F. , Erkisa, M., Khodadust, R., Ari, F., Ulukaya, E. and Yagci Acar, H. (2017) Folic acid-conjugated cationic Ag2S quantum dots for optical imaging and selective doxorubicin delivery to HeLa cells. Nanomedicine, 12(19), pp. 2319-2333. (doi: 10.2217/nnm-2017-0180) (PMID:28875744)
Full text not currently available from Enlighten.
Abstract
Aim: We aim to develop folic acid (FA)-conjugated cationic Ag2S near-infrared quantum dots (NIRQDs) for the delivery of doxorubicin (DOX) selectively to folate receptor (FR)-positive cancer cells to achieve enhanced drug efficacy and optical tracking in the NIR region. Materials & methods: Cationic Ag2S NIRQDs were decorated with FA using a PEG bridge and loaded with DOX. In vitro studies were performed on FR-positive human cervical carcinoma cells and FR-negative A549 cells. Results: Significantly higher uptake of DOX by human cervical carcinoma cells cells and a greater therapeutic effect along with a strong intracellular optical signal were obtained with DOX-loaded FA-conjugated Ag2S NIRQDs. Conclusion: These Ag2S NIRQDs are promising theranostic nanoparticles for receptor-mediated delivery of DOX with enhanced drug efficacy combined with optical imaging.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Demir Duman, Dr Fatma |
| Authors: | Demir Duman, F., Erkisa, M., Khodadust, R., Ari, F., Ulukaya, E., and Yagci Acar, H. |
| Subjects: | Q Science > QD Chemistry R Medicine > RM Therapeutics. Pharmacology |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Nanomedicine |
| Publisher: | Future Medicine |
| ISSN: | 1743-5889 |
| ISSN (Online): | 1748-6963 |
| Published Online: | 06 September 2017 |
University Staff: Request a correction | Enlighten Editors: Update this record
Deposit and Record Details
Deposit and Record Details