Bisphosphonate-functionalized poly (β-amino ester) network polymers

Guven, M. N., Seckin Altuncu, M., Demir Duman, F. , Eren, T. N., Yagci Acar, H. and Avci, D. (2017) Bisphosphonate-functionalized poly (β-amino ester) network polymers. Journal of Biomedical Materials Research Part A, 105(5), pp. 1412-1421. (doi: 10.1002/jbm.a.36026) (PMID:28165665)

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Abstract

Three novel bisphosphonate‐functionalized secondary diamines are synthesized and incorporated into poly(β‐amino ester)s (PBAEs) to investigate the effects of bisphosphonates on biodegradation and toxicity of PBAE polymer networks. These three novel amines, BPA1, BPA2, and BPA3, were prepared from the reactions of 1,4‐butanediamine, 1,6‐hexanediamine, or 4,9‐dioxa‐1,12‐dodecanediamine with tetraethyl vinylidene bisphosphonate, respectively. The PBAE macromers were obtained from the aza‐Michael addition reaction of these amines to 1,6‐hexane diol diacrylate (HDDA) and poly(ethylene glycol) diacrylate (PEGDA, Mn = 575) and photopolymerized to produce biodegradable gels. These gels with different chemistries exhibited similar degradation behavior with mass loss of 53–73% within 24 h, indicating that degradation is mostly governed by the bisphosphonate group. Based on the in vitro cytotoxicity evaluation against NIH 3T3 mouse embryonic fibroblast cells, the degradation products do not exhibit significant toxicity in most cases. It was also shown that PBAE macromers can be used as cross‐linkers for the synthesis of 2‐hydroxyethyl methacrylate hydrogels, conferring small and customizable degradation rates upon them. The materials reported have potential to be used as nontoxic degradable biomaterials.

Item Type:Articles
Additional Information:The authors are pleased to acknowledge the financial support from TÜBİTAK (114Z926).
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Demir Duman, Dr Fatma
Authors: Guven, M. N., Seckin Altuncu, M., Demir Duman, F., Eren, T. N., Yagci Acar, H., and Avci, D.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Journal of Biomedical Materials Research Part A
Publisher:Wiley
ISSN:1549-3296
ISSN (Online):1552-4965
Published Online:06 February 2017

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