Alkhaldi, A.A.M., De Koning, H.P. and Bukhari, S.N.A. (2019) Effects of some natural leads on Trypanosoma and Leishmania strains. Tropical Biomedicine, 36(2), pp. 373-378.
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Publisher's URL: http://msptm.org/files/Vol36No2/373-378-Bukhari-SNA.pdf
Abstract
Well-known medical herbal compounds including apigenin, daidzein, phyllanthin and tyramine were assessed against Trypanosoma and Leishmania protozoans. Two strains of the bloodstream forms of Trypanosoma brucei: s427-WT and TbAT1-B48, and Leishmania major and Leishmania mexicana promastigotes were utilised. Among selected natural compounds, apigenin and daidzein displayed moderate activity against African trypanosomes with EC50 16 µM for wild-type sensitive control strain. Tyramine was not found to be very active for trypanosomes strains while all compounds were found to have trivial activity for the inhibition of Leishmania mexicana strains.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | De Koning, Professor Harry |
Authors: | Alkhaldi, A.A.M., De Koning, H.P., and Bukhari, S.N.A. |
College/School: | College of Medical Veterinary and Life Sciences > School of Infection & Immunity |
Journal Name: | Tropical Biomedicine |
Publisher: | Malaysian Society of Parasitology and Tropical Medicine |
ISSN: | 2521-9855 |
Copyright Holders: | Copyright © 2019 Tropical Biomedicine |
First Published: | First published in Tropical Biomedicine 36(2): 373-378 |
Publisher Policy: | Reproduced with the permission of the Publisher |
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