Mixed candida albicans and candida glabrata populations associated with the pathogenesis of denture stomatitis

Coco, B.J., Bagg, J., Cross, L.J., Jose, A., Cross, J. and Ramage, G. (2008) Mixed candida albicans and candida glabrata populations associated with the pathogenesis of denture stomatitis. Oral Microbiology and Immunology, 23(5), pp. 377-383. (doi:10.1111/j.1399-302X.2008.00439.x)

Coco, B.J., Bagg, J., Cross, L.J., Jose, A., Cross, J. and Ramage, G. (2008) Mixed candida albicans and candida glabrata populations associated with the pathogenesis of denture stomatitis. Oral Microbiology and Immunology, 23(5), pp. 377-383. (doi:10.1111/j.1399-302X.2008.00439.x)

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Abstract

<p>Introduction:  Oral yeasts are an important component of the resident microbial ecology of the oral cavity, but they are also associated with various forms of oral candidosis, such as denture stomatitis. Although Candida albicans is the predominant oral fungal pathogen, other species may also play an integral role in pathogenesis. The aim of this study was to examine the mycological ecology in patients with denture stomatitis, using an improved sampling technique, to determine whether species diversity and species quantity were related to oral pathology.</p> <p>Methods:  Thirty-seven patients attending the Glasgow Dental Hospital were enrolled in this study following informed consent. A full clinical history was obtained, including details of their oral hygiene practices and the levels of erythema based on Newton’s classification scale. Oral rinse, denture sonicate, and swab samples were taken, which were processed for quantitative and qualitative analysis of oral yeasts.</p> <p>Results:  The proportion of patients with no inflammation or Newton’s Types I, II, and III were 31, 33, 25, and 14%, respectively. Denture sonication was a superior sampling procedure, with statistically greater quantities of yeasts isolated using this methodology (P < 0.01). The predominant oral yeasts isolated were C. albicans (75%) and Candida glabrata (30%), which were isolated in higher proportions in patients with the highest grades of inflammation (100 and 80%), and in combination from 80% of these patients.</p> <p>Conclusions:  This study has demonstrated that mixed C. albicans and C. glabrata biofilms may play an important role in the pathogenesis associated with severe inflammation in denture wearers.</p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Ramage, Professor Gordon and Jose, Mr Anto and Bagg, Professor Jeremy
Authors: Coco, B.J., Bagg, J., Cross, L.J., Jose, A., Cross, J., and Ramage, G.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Dental School
Journal Name:Oral Microbiology and Immunology
Publisher:Wiley-Blackwell Publishing, Inc.
ISSN:2041-1006
ISSN (Online):1399-302X
Published Online:08 August 2008

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