The relationship between tumour proliferative activity, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer

Canna, K., Hilmy, M., McMillan, D.C. , Smith, G.W., McKee, R.F., McArdle, C.S. and McNicol, A. (2008) The relationship between tumour proliferative activity, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer. Colorectal Disease, 10(7), pp. 663-667. (doi:10.1111/j.1463-1318.2007.01416.x)

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Abstract

<p><b>Background</b> The aim of the present study was to examine the relationship between Ki-67, C-reactive protein and cancer-specific survival in patients undergoing resection for colorectal cancer.</p> <p><b>Method</b> One hundred and forty-seven patients undergoing potentially curative resection for colorectal cancer had preoperative C-reactive protein concentrations and tumour Ki-67 labelling index measured.</p> <p><b>Results</b> On univariate analysis, age (P < 0.001), Dukes stage (P < 0.001), C-reactive protein (P < 0.001) and expression of Ki-67 (< 0.01) were associated with poorer cancer-specific survival. Ki-67 labelling index and C-reactive protein were correlated (rs = 0.172, P = 0.037). On multivariate analysis, age (HR 1.96, 95% CI 1.26–3.04, P = 0.003), Dukes stage (HR 4.38, 95% CI 2.11–9.09, P < 0.001) and C-reactive protein (HR 4.09, 95% CI 2.04–8.24, P < 0.001) retained significance.</p> <p><b>Conclusion</b> Increased tumour proliferation is associated with a systemic inflammatory response and poor cancer-specific survival in patients undergoing potentially curative surgery for colorectal cancer.</p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McKee, Dr Ruth and McMillan, Professor Donald and McNicol, Dr Anne-Marie
Authors: Canna, K., Hilmy, M., McMillan, D.C., Smith, G.W., McKee, R.F., McArdle, C.S., and McNicol, A.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:Colorectal Disease
ISSN:1462-8910
Published Online:14 November 2007

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