The relationship between tumour proliferative activity, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer

Canna, K., Hilmy, M., McMillan, D.C., Smith, G.W., McKee, R.F., McArdle, C.S. and McNicol, A. (2008) The relationship between tumour proliferative activity, the systemic inflammatory response and survival in patients undergoing curative resection for colorectal cancer. Colorectal Disease, 10(7), pp. 663-667. (doi: 10.1111/j.1463-1318.2007.01416.x)

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Abstract

<p><b>Background</b> The aim of the present study was to examine the relationship between Ki-67, C-reactive protein and cancer-specific survival in patients undergoing resection for colorectal cancer.</p> <p><b>Method</b> One hundred and forty-seven patients undergoing potentially curative resection for colorectal cancer had preoperative C-reactive protein concentrations and tumour Ki-67 labelling index measured.</p> <p><b>Results</b> On univariate analysis, age (P < 0.001), Dukes stage (P < 0.001), C-reactive protein (P < 0.001) and expression of Ki-67 (< 0.01) were associated with poorer cancer-specific survival. Ki-67 labelling index and C-reactive protein were correlated (rs = 0.172, P = 0.037). On multivariate analysis, age (HR 1.96, 95% CI 1.26–3.04, P = 0.003), Dukes stage (HR 4.38, 95% CI 2.11–9.09, P < 0.001) and C-reactive protein (HR 4.09, 95% CI 2.04–8.24, P < 0.001) retained significance.</p> <p><b>Conclusion</b> Increased tumour proliferation is associated with a systemic inflammatory response and poor cancer-specific survival in patients undergoing potentially curative surgery for colorectal cancer.</p>

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McKee, Dr Ruth and McMillan, Professor Donald and McNicol, Dr Anne-Marie
Authors: Canna, K., Hilmy, M., McMillan, D.C., Smith, G.W., McKee, R.F., McArdle, C.S., and McNicol, A.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing > Clinical Specialities
Journal Name:Colorectal Disease
ISSN:1462-8910
Published Online:14 November 2007

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