On the use of Lonafarnib in myelodysplastic syndrome and chronic myelomonocytic leukemia

Feldman, E. et al. (2008) On the use of Lonafarnib in myelodysplastic syndrome and chronic myelomonocytic leukemia. Leukemia, 22(9), pp. 1707-1711. (doi: 10.1038/leu.2008.156)

Abstract

Lonafarnib is an orally bio-available farnesyltransferase inhibitor that prevents farnesylation of specific target proteins including Ras. In a multicenter study, 67 patients with advanced myelodysplastic syndrome (MDS) and chronic myelomonocytic leukemia (CMML) were treated with a continuous oral dose of 200 -300mg of lonafarnib and were evaluated for hematologic, pathologic and pharmacodynamic response. The median age of patients was 70 years (range 44 -86). There were 32 patients with MDS (RAEB-20 and RAEB-t-12) and 35 with CMML. Overall 16 (24%) of the patients responded with two patients achieving a complete remission and one a partial response. Responses were seen in 6/32 and 10/35 patients with MDS and CMML, respectively. Of the 19 patients who were platelet transfusion-dependent prior to treatment, 5 (26%) became transfusion-free for a median duration of 185 days. A decrease in the farnesylation of the HDJ-2 protein measured in patient-derived cells was observed in the majority of patients during treatment with lonafarnib, but no clear correlation between changes in farnesylation and clinical effect could be made. Gastrointestinal toxicity was significant with 19% of patients discontinuing therapy due to diarrhea, nausea and/or anorexia. Lonafarnib has demonstrable activity in patients with advanced MDS and CMML.

• Item Type: Articles
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: Holyoake, Professor Tessa
• Authors: Feldman, E., Cortes, J., DeAngelo, D., Holyoake, T., Simonsson, B., O'Brien, S., Reiffers, J., Turner, A., Roboz, G., Lipton, J., Maloisel, F., Colombat, P., Martinelli, G., Nielsen, J., Petersdorf, S., Guilhot, F., Barker, J., Kirschmeier, P., Frank, E., Statkevich, P., and Zhu, Y.
• College/School: College of Medical Veterinary and Life Sciences > School of Cancer Sciences
• Journal Name: Leukemia
• ISSN: 0887-6924