New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter

Jobson, N., Crawford, A., Dewar, D., Pimlott, S. and Sutherland, A. (2008) New iodoreboxetine analogues for SPECT imaging of the noradrenaline transporter. Bioorganic and Medicinal Chemistry Letters, 18(18), pp. 4940-4943. (doi: 10.1016/j.bmcl.2008.08.041)

Full text not currently available from Enlighten.

Abstract

A new route for the stereoselective synthesis of iodinated reboxetine analogues has been developed for the generation of SPECT imaging agents for the noradrenaline transporter (NAT). (2S,3S)- and (2R,3R)-iodoreboxetine were prepared and biological testing against various mono-amine transporters showed these compounds to be potent and selective for NAT.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Dewar, Dr Deborah and Pimlott, Dr Sally and Sutherland, Professor Andrew
Authors: Jobson, N., Crawford, A., Dewar, D., Pimlott, S., and Sutherland, A.
College/School:College of Medical Veterinary and Life Sciences > Institute of Neuroscience and Psychology
College of Science and Engineering > School of Chemistry
Journal Name:Bioorganic and Medicinal Chemistry Letters
ISSN:0960-894X

University Staff: Request a correction | Enlighten Editors: Update this record