Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain

Sills, G. J., Leach, J. P. , Fraser, C. M., Forrest, G., Patsalos, P. N. and Brodie, M. J. (1997) Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain. European Journal of Pharmacology, 325(1), pp. 35-40. (doi:10.1016/S0014-2999(97)00105-2) (PMID:9151936)

Sills, G. J., Leach, J. P. , Fraser, C. M., Forrest, G., Patsalos, P. N. and Brodie, M. J. (1997) Neurochemical studies with the novel anticonvulsant levetiracetam in mouse brain. European Journal of Pharmacology, 325(1), pp. 35-40. (doi:10.1016/S0014-2999(97)00105-2) (PMID:9151936)

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Abstract

Levetiracetam is a novel antiepileptic agent with a wide spectrum of activity against experimental and clinical seizures. The mechanism of its anticonvulsant action remains to be determined. We have investigated the effects of levetiracetam on several γ-aminobutyric acid (GABA)-related neurochemical parameters in mouse brain. Adult male mice were randomised into two groups and administered levetiracetam (0–300 mg/kg) intraperitoneally either as a single dose or twice daily for 5 days. Four hours after the final dose, animals were killed and their brains removed. Brain tissues were analysed for concentrations of GABA, glutamate and glutamine and for the activities of GABA-transaminase and glutamic acid decarboxylase. Single dose and repeated levetiracetam treatments were without effect on all of the parameters investigated. The anticonvulsant action of levetiracetam is unlikely to be mediated via an action on the GABAergic system.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Brodie, Professor Martin and Leach, Dr John Paul and Forrest, Mr Gerard and Sills, Dr Graeme
Authors: Sills, G. J., Leach, J. P., Fraser, C. M., Forrest, G., Patsalos, P. N., and Brodie, M. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cancer Sciences
College of Medical Veterinary and Life Sciences > School of Life Sciences
College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
Journal Name:European Journal of Pharmacology
Publisher:Elsevier
ISSN:0014-2999
ISSN (Online):1879-0712

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