The relationship between body mass index and short term postoperative outcomes in patients undergoing potentially curative surgery for colorectal cancer: a systematic review and meta-analysis

Almasaudi, A. S., McSorley, S. T. , Edwards, C. A. and McMillan, D. C. (2018) The relationship between body mass index and short term postoperative outcomes in patients undergoing potentially curative surgery for colorectal cancer: a systematic review and meta-analysis. Critical Reviews in Oncology/Hematology, 121, pp. 68-73. (doi: 10.1016/j.critrevonc.2017.12.004) (PMID:29279101)

Abstract

Background: The prevalence of obesity has increased worldwide over the last few decades, and is a well-recognized risk factor for colorectal cancer. Surgical site infection is the most frequent complication following surgery for colorectal cancer, and the main cause of postoperative morbidity. The aim of the present systematic review and meta-analysis was to examine the relationship between increasing BMI and postoperative surgical site infection following surgery for colorectal cancer. Methods: A systemic literature search was conducted using Medline, PubMed, Embase (Ovid) and Web of Science databases from inception to the end of August 2016. Studies examining the relationship between obesity and surgical site infection following surgery for colorectal cancer were included. Analysis of the data was performed using Review Manager version 5.3(The Nordic Cochrane Centre, The Cochrane Collaboration, Copen-hagen, Denmark,) Results: In this meta-analysis, a total of 9535 patients from 16 studies were included. BMI <30 vs ≥30 kg/m2 was used to examine the association of obesity and surgical site infection in patients from Western countries. The estimated pooled OR demonstrated that obesity increased the risk of surgical site infection by approximately 100% (OR = 2.13; 95% CI 1.66-2.72, p < 0.001).BMI <25 vs ≥25 kg/m2 was used to examine the association of obesity and surgical site infection from Asian countries. The estimated pooled OR demonstrated that obesity increased the risk of surgical site infection by approximately 60% (OR = 1.63; 95% CI 1.29-2.06, p < 0.001). There was little evidence of publication bias in the meta-analysis. Conclusion: From this systematic review and meta-analysis there was good evidence that obesity was associated with a significantly higher risk of developing surgical site infection following surgery for colorectal cancer in both ethnic groups. The magnitude of the effect warrants further investigation.

• Item Type: Articles
• Additional Information: This work was supported by the Faculty of Applied Medical Science, Clinical Nutrition Department at King Abdulaziz University, Jeddah, Kingdom of Saudi Arabia.
• Status: Published
• Refereed: Yes
• Glasgow Author(s) Enlighten ID: McMillan, Professor Donald and McSorley, Dr Stephen and Edwards, Professor Christine and Almasaudi, Arwa
• Authors: Almasaudi, A. S., McSorley, S. T., Edwards, C. A., and McMillan, D. C.
• College/School: College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
• Journal Name: Critical Reviews in Oncology/Hematology
• Publisher: Elsevier
• ISSN: 1040-8428
• ISSN (Online): 1879-0461
• Published Online: 07 December 2017
• Copyright Holders: Copyright © 2017 Elsevier B.V.
• First Published: First published in Critical Reviews in Oncology/Hematology 121: 68-73
• Publisher Policy: Reproduced in accordance with the publisher copyright policy