Probing the self-assembled structures and pKa of hydrogels using electrochemical methods

Cross, E. R. and Adams, D. J. (2019) Probing the self-assembled structures and pKa of hydrogels using electrochemical methods. Soft Matter, 15(7), pp. 1522-1528. (doi: 10.1039/C8SM02430H) (PMID:30681698)

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The surface chemistry of the aggregated structures that form the scaffold in self-assembled hydrogels - their charge, hydrophobicity and ion-binding dynamics - play an important role in determining the gel properties and the gel’s suitability for specific applications. However, there are limited methods available for the study of this surface chemistry. Here, we show that electrochemical techniques can be used to measure the surface chemical properties of the self-assembled aggregates structures and also to determine the pKa of the gelators. We also provide a method to quickly determine whether a functionalised-dipeptide will form either a gel or not. This method has scope for use in use in high-throughput screening and further complex pH-triggered self-assembled gelation systems.

Item Type:Articles
Glasgow Author(s) Enlighten ID:Adams, Dave and Cross, Emily
Authors: Cross, E. R., and Adams, D. J.
College/School:College of Science and Engineering > School of Chemistry
Journal Name:Soft Matter
Publisher:Royal Society of Chemistry
ISSN (Online):1744-6848
Published Online:14 January 2019
Copyright Holders:Copyright © 2019 The Authors
First Published:First published in Soft Matter 15(7): 1522-1528
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
768041Multicomponent Supramolecular HydrogelsDave AdamsEngineering and Physical Sciences Research Council (EPSRC)EP/L021978/2SCHOOL OF CHEMISTRY