Cross, E. R. and Adams, D. J. (2019) Probing the self-assembled structures and pKa of hydrogels using electrochemical methods. Soft Matter, 15(7), pp. 1522-1528. (doi: 10.1039/C8SM02430H) (PMID:30681698)
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Abstract
The surface chemistry of the aggregated structures that form the scaffold in self-assembled hydrogels - their charge, hydrophobicity and ion-binding dynamics - play an important role in determining the gel properties and the gel’s suitability for specific applications. However, there are limited methods available for the study of this surface chemistry. Here, we show that electrochemical techniques can be used to measure the surface chemical properties of the self-assembled aggregates structures and also to determine the pKa of the gelators. We also provide a method to quickly determine whether a functionalised-dipeptide will form either a gel or not. This method has scope for use in use in high-throughput screening and further complex pH-triggered self-assembled gelation systems.
| Item Type: | Articles |
|---|---|
| Status: | Published |
| Refereed: | Yes |
| Glasgow Author(s) Enlighten ID: | Adams, Dave and Cross, Emily |
| Authors: | Cross, E. R., and Adams, D. J. |
| College/School: | College of Science and Engineering > School of Chemistry |
| Journal Name: | Soft Matter |
| Publisher: | Royal Society of Chemistry |
| ISSN: | 1744-683X |
| ISSN (Online): | 1744-6848 |
| Published Online: | 14 January 2019 |
| Copyright Holders: | Copyright © 2019 The Authors |
| First Published: | First published in Soft Matter 15(7): 1522-1528 |
| Publisher Policy: | Reproduced under a Creative Commons License |
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