Metabolic and structural skeletal muscle health in systemic lupus erythematosus related fatigue: a multi-modal magnetic resonance imaging study

Cheung, S. M. et al. (2019) Metabolic and structural skeletal muscle health in systemic lupus erythematosus related fatigue: a multi-modal magnetic resonance imaging study. Arthritis Care and Research, (doi:10.1002/acr.23833) (PMID:30629805) (Early Online Publication)

Cheung, S. M. et al. (2019) Metabolic and structural skeletal muscle health in systemic lupus erythematosus related fatigue: a multi-modal magnetic resonance imaging study. Arthritis Care and Research, (doi:10.1002/acr.23833) (PMID:30629805) (Early Online Publication)

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Abstract

Objective: This study aimed to investigate the potential structural and metabolic role of skeletal muscle in SLE related fatigue. Methods: A case control, multi-modal MRI study was conducted. Cases were inactive SLE patients who reported chronic fatigue. Controls were age/sex matched healthy members of the general population. Participants were clinically characterised and then underwent a 3T whole body MRI scan. Resting and dynamic 31 Phosphorous Magnetic Resonance Spectroscopy (MRS) of the calf muscles was applied from which phosphocreatine recovery half time (PCr), a marker of mitochondrial dysfunction, was computed. In addition, microstructural sequences (T1-weighted anatomical images, T2 mapping and diffusion tensor imaging) were acquired. Descriptive statistics evaluated group differences and within case physical fatigue correlations were explored. Results: Of the 37 recruits (mean age= 43.8 years, 89.2% female), cases (n=19) reported higher levels of physical fatigue, pain, depression and sleep disturbance compared to the control group (p<0.0001). PCr was greater (p=0.045) among cases (33.0+/-9.0s) compared to controls (27.1+/-6.6s). No micro-structural group differences were observed. Within cases, physical fatigue did not correlate with PCr (r=-0.28, p=0.25). Conclusion: We report preliminary data evidencing greater skeletal muscle mitochondrial dysfunction among fatigued SLE patients compared to healthy controls.

Item Type:Articles
Additional Information:This work was supported by Lupus UK
Status:Early Online Publication
Refereed:Yes
Glasgow Author(s) Enlighten ID:Basu, Dr Neil and Gray, Dr Stuart
Authors: Cheung, S. M., Keenan, K., Senn, N., Hutcheon, G., Chan, K., Erwig, L., Schrepf, A., Dospinescu, P., Gray, S., Waiter, G., He, J., and Basu, N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Arthritis Care and Research
Publisher:Wiley
ISSN:2151-464X
ISSN (Online):2151-4658
Published Online:10 January 2019
Copyright Holders:Copyright © 2019 John Wiley and Sons Ltd
First Published:First published in Arthritis Care and Research 2019
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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