Kwan, P., Sills, G. J., Butler, E., Gant, T. W. and Brodie, M. J. (2003) Differential expression of multidrug resistance genes in naïve rat brain. Neuroscience Letters, 339(1), pp. 33-6. (PMID:12618294)
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Abstract
The multidrug resistance (mdr1) gene family encodes the efflux transporter P-glycoprotein (P-gp) which contributes to the functionality of the blood-brain barrier. We have characterised the regional expression of mdr1 genes in nai;ve rat brain. Adult male Sprague-Dawley rats (n=6) were sacrificed and their brains rapidly removed. Seven distinct anatomical regions were isolated by microdissection and the expression of mdr1a and mdr1b determined by quantitative reverse-transcriptase polymerase chain reaction. The mdr1a isoform was expressed in all brain regions investigated, while mdr1b was expressed to a quantifiable degree in hippocampus alone. These findings reveal a differential expression of mdr1 genes in normal rodent brain tissue and suggest that P-gp may afford a broader protection of the hippocampus than other brain structures.
Item Type: | Articles |
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Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Sills, Dr Graeme |
Authors: | Kwan, P., Sills, G. J., Butler, E., Gant, T. W., and Brodie, M. J. |
College/School: | College of Medical Veterinary and Life Sciences |
Journal Name: | Neuroscience Letters |
Publisher: | Elsevier |
ISSN: | 0304-3940 |
ISSN (Online): | 1872-7972 |
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