Dreyer, S. B. et al. (2020) Precision oncology in surgery: patient selection for operable pancreatic cancer. Annals of Surgery, 272(2), pp. 366-376. (doi: 10.1097/SLA.0000000000003143) (PMID:32675551) (PMCID:PMC7373491)
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Abstract
Objective: We aimed to define preoperative clinical and molecular characteristics that would allow better patient selection for operative resection. Background: Although we use molecular selection methods for systemic targeted therapies, these principles are not applied to surgical oncology. Improving patient selection is of vital importance for the operative treatment of pancreatic cancer (pancreatic ductal adenocarcinoma). Although surgery is the only chance of long-term survival, 80% still succumb to the disease and approximately 30% die within 1 year, often sooner than those that have unresected local disease. Method: In 3 independent pancreatic ductal adenocarcinoma cohorts (total participants = 1184) the relationship between aberrant expression of prometastatic proteins S100A2 and S100A4 and survival was assessed. A preoperative nomogram based on clinical variables available before surgery and expression of these proteins was constructed and compared to traditional measures, and a postoperative nomogram. Results: High expression of either S100A2 or S100A4 was independent poor prognostic factors in a training cohort of 518 participants. These results were validated in 2 independent patient cohorts (Glasgow, n = 198; Germany, n = 468). Aberrant biomarker expression stratified the cohorts into 3 distinct prognostic groups. A preoperative nomogram incorporating S100A2 and S100A4 expression predicted survival and nomograms derived using postoperative clinicopathological variables. Conclusions: Of those patients with a poor preoperative nomogram score, approximately 50% of patients died within a year of resection. Nomograms have the potential to improve selection for surgery and neoadjuvant therapy, avoiding surgery in aggressive disease, and justifying more extensive resections in biologically favorable disease.
Item Type: | Articles |
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Additional Information: | The study was supported by Wellcome Trust Senior Investigator Award: 103721/Z/14/Z; Cancer Research UK Programme: C29717/ A17263 and C29717/A18484; Cancer Research UK Glasgow Centre: C596/ A18076; Cancer Research UK Clinical Training Award: C596/A20921; Scottish Genome Partnership SEHHD-CSO 1175759/2158447; Pancreatic Cancer UK Future Research Leaders Fund FLF2015_04_Glasgow; MRC/EPSRC Glasgow Molecular Pathology Node; The Howat Foundation; Precision Panc; The National Health and Medical Research Council of Australia, The Cancer Council NSW, Cancer Institute NSW, Royal Australasian College of Surgeons, St Vincent’s Clinic Foundation and R. T. Hall Trust; and The Avner Pancreatic Cancer Foundation. |
Status: | Published |
Refereed: | Yes |
Glasgow Author(s) Enlighten ID: | Jamieson, Professor Nigel and Dreyer, Dr Stephan and Cooke, Dr Susie and Biankin, Professor Andrew and Carter, Mr Ross and Moran-Jones, Dr Kim and Jones, Mr Marc and Bailey, Dr Peter and Musgrove, Dr Elizabeth and Duthie, Dr Fraser and McKay, Mr Colin and Chang, Professor David |
Authors: | Dreyer, S. B., Pinese, M., Jamieson, N. B., Scarlett, C. J., Colvin, E. K., Pajic, M., Johns, A. L., Humphris, J. L., Wu, J., Cowley, M. J., Chou, A., Nagrial, A. M., Chantrill, L., Chin, V. T., Jones, M. D., Moran-Jones, K., Carter, C. R., Dickson, E. J., Samra, J. S., Merrett, N. D., Gill, A. J., Kench, J. G., Duthie, F., Miller, D. K., Cooke, S., Aust, D., Knösel, T., Rümmele, P., Grützmann, R., Pilarsky, C., Nguyen, N. Q., Musgrove, E. A., Bailey, P. J., McKay, C. J., Biankin, A. V., and Chang, D. K. |
College/School: | College of Medical Veterinary and Life Sciences > School of Cancer Sciences College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing |
Journal Name: | Annals of Surgery |
Publisher: | Lippincott, Williams and Wilkins |
ISSN: | 0003-4932 |
ISSN (Online): | 1528-1140 |
Published Online: | 30 November 2018 |
Copyright Holders: | Copyright © 2018 The Authors |
First Published: | First published in Annals of Surgery 272(2): 366-376 |
Publisher Policy: | Reproduced under a Creative Commons License |
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