The association of insulin-like-growth factor 1 (IGF-1) with incident coronary heart disease in women: Findings from the prospective British Women's Heart and Health Study

Lawlor, D., Ebrahim, S., Davey Smith, G., Cherry, L., Watt, P. and Sattar, N. (2008) The association of insulin-like-growth factor 1 (IGF-1) with incident coronary heart disease in women: Findings from the prospective British Women's Heart and Health Study. Atherosclerosis, 201(1), pp. 198-204. (doi:10.1016/j.atherosclerosis.2007.12.061)

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Abstract

Objective: To examine the association of insulin-like-growth factor 1 (IGF-1) with coronary heart disease (CHD) in women. Methods: Prospective (4 year) case-control study nested within the British Women's Heart and Health Study. With 167 cases and 333 controls. Serum IGF-1 concentrations (on serum stored at -80 degrees C for a median of 4 years) were determined using a two-site immunoenzymometric assay. Results: Among, both cases and controls IGF-1 wits inversely correlated with waist:hip ratio, fasting insulin, HOMA-IR. CRR triglyceride levels and systolic blood pressure, and wits positively correlated with HDL-C levels. The confounder-adjusted (age, socioeconomic position, smoking and physical activity) relative risk ratio for it 1 standard deviation (S.D.) increase in IGF-1 was 0.92 (95% CI: 0.75, 1.12) and additional adjustment for metabolic risk factors (waist:hip ratio, systolic blood pressure, high-density lipoprotein cholesterol. triglycerides, glucose, insulin and C-reactive protein) attenuated this to 0.98 (95% CI: 0.80, 1.21). There was no evidence of non-linear associations and the risk of CHD was similar across quarters of the distribution of IGF-1. Conclusions: Despite associations with established CHD risk factors in this. and other studies, Our findings suggest that higher IGF-1 levels are not associated with CHD in older British women. The contradictory evidence to date in this area highlights the need for further prospective studies and use of genetic epidemiology studies to determine the nature of the association between IGF-1 and CHD.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Cherry, Mrs Lynne and Davey Smith, Professor George and Watt, Miss Pauline and Sattar, Professor Naveed
Authors: Lawlor, D., Ebrahim, S., Davey Smith, G., Cherry, L., Watt, P., and Sattar, N.
College/School:College of Medical Veterinary and Life Sciences > Institute of Cardiovascular and Medical Sciences
College of Medical Veterinary and Life Sciences
Journal Name:Atherosclerosis
Publisher:Elsevier Ireland Ltd
ISSN:0021-9150
ISSN (Online):1879-1484

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