A major step towards defining the elusive stumpy inducing factor in Trypanosoma brucei

Sollelis, L. and Marti, M. (2018) A major step towards defining the elusive stumpy inducing factor in Trypanosoma brucei. Trends in Parasitology, 35(1), pp. 6-8. (doi:10.1016/j.pt.2018.11.009) (PMID:30554967)

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Abstract

Trypanosoma brucei stumpy forms are the only stage that can transmit from human to tsetse fly. Stumpy formation is regulated by a quorum sensing mechanism that depends on parasite density and an unknown stumpy induction factor (SIF). Recently, an elegant study by Matthews and colleagues (Cell 176, 1-12) has identified several crucial components of this pathway, including the putative SIF and its receptor.

Item Type:Articles
Keywords:Trypanosoma brucei, differentiation, sleeping sickness, slender form, stumpy form, stumpy inducing factor.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Sollelis, Miss Lauriane and Marti, Professor Matthias
Authors: Sollelis, L., and Marti, M.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Trends in Parasitology
Publisher:Elsevier
ISSN:1471-4922
ISSN (Online):1471-5007
Copyright Holders:Copyright © 2018 Elsevier Ltd.
First Published:First published in Trends in Parasitology 35(1):6-8
Publisher Policy:Reproduced in accordance with the copyright policy of the publisher

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