Plasmacytoid dendritic cells regulate breach of self-tolerance in autoimmune arthritis

Jongbloed, S.L., Benson, R., Nickdel, M.B., Garside, P. , McInnes, I. and Brewer, J.M. (2009) Plasmacytoid dendritic cells regulate breach of self-tolerance in autoimmune arthritis. Journal of Immunology, 182(2), pp. 963-968. (doi:10.4049/jimmunol.182.2.963) (PMID:19124739)

Jongbloed, S.L., Benson, R., Nickdel, M.B., Garside, P. , McInnes, I. and Brewer, J.M. (2009) Plasmacytoid dendritic cells regulate breach of self-tolerance in autoimmune arthritis. Journal of Immunology, 182(2), pp. 963-968. (doi:10.4049/jimmunol.182.2.963) (PMID:19124739)

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Publisher's URL: http://www.jimmunol.org/content/182/2/963.long

Abstract

Achieving remission in rheumatoid arthritis (RA) remains elusive despite current biological therapeutics. Consequently, interest has increased in strategies to re-establish immune tolerance to provide long-term disease suppression. Although dendritic cells (DC) are prime candidates in initiating autoreactive T cell responses, and their presence within the synovial environment suggests a role in generation and maintenance of autoreactive, synovial T cell responses, their functional importance remains unclear. We investigated the contribution made by plasmacytoid DCs (pDCs) in the spontaneous breach of tolerance to arthritis-related self proteins, including rheumatoid factor, citrullinated peptide, and type II collagen observed in a novel arthritis model. Selective pDC depletion in vivo enhanced the severity of articular pathology and enhanced T and B cell autoimmune responses against type II collagen. pDC may offer a net anti-inflammatory function in the context of articular breach of tolerance. Such data will be vital in informing DC modulatory/therapeutic approaches.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:McInnes, Professor Iain and Nickdel, Dr Mohammad and Brewer, Professor James and Garside, Professor Paul and Jongbloed, Miss Sarah and Benson, Dr Robert
Authors: Jongbloed, S.L., Benson, R., Nickdel, M.B., Garside, P., McInnes, I., and Brewer, J.M.
College/School:College of Medical Veterinary and Life Sciences
College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Journal of Immunology
Journal Abbr.:J. Immunol.
ISSN:0022-1767
ISSN (Online):1550-6606

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