Modulation of host immunity by helminths: the expanding repertoire of parasite effector molecules

Maizels, R. , Smits, H. H. and McSorley, H. J. (2018) Modulation of host immunity by helminths: the expanding repertoire of parasite effector molecules. Immunity, 49(5), pp. 801-818. (doi:10.1016/j.immuni.2018.10.016) (PMID:30462997) (PMCID:PMC6269126)

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Abstract

Helminths are extraordinarily successful parasites due to their ability to modulate the host immune response. They have evolved a spectrum of immunomodulatory molecules that are now beginning to be defined, heralding a molecular revolution in parasite immunology. These discoveries have the potential both to transform our understanding of parasite adaptation to the host and to develop possible therapies for immune-mediated disease. In this review we will summarize the current state of the art in parasite immunomodulation and discuss perspectives on future areas for research and discovery.

Item Type:Articles
Additional Information:R.M.M. is supported by the Wellcome Trust through an Investigator Award (106122), by the Kenneth Rainin Foundation (2016-3067), and by core funding to the Wellcome Centre for Molecular Parasitology (104111). H.H.S. is supported by a ZonMW-VIDI grant (91714352) from the Netherlands Organisation for Scientific Research and a Consortium Grant (5115015) from the Netherlands Lung Foundation. R.M.M., H.H.S., and H.J.M. are supported by a Consortium grant (12017001) from the Netherlands Lung Foundation Accelerate Programme.
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Maizels, Professor Rick
Authors: Maizels, R., Smits, H. H., and McSorley, H. J.
College/School:College of Medical Veterinary and Life Sciences > Institute of Infection Immunity and Inflammation
Journal Name:Immunity
Publisher:Elsevier
ISSN:1074-7613
ISSN (Online):1097-4180
Published Online:20 November 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Immunity 49:801-818
Publisher Policy:Reproduced under a Creative Commons License

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Project CodeAward NoProject NamePrincipal InvestigatorFunder's NameFunder RefLead Dept
765221Helminths and the Immune System: Regulation, Regulators and ImmunityRichard MaizelsWellcome Trust (WELLCOTR)106122/A/14/ZIII - PARASITOLOGY
371799The Wellcome Centre for Molecular Parasitology ( Core Support )Andrew WatersWellcome Trust (WELLCOTR)104111/Z/14/Z & AIII - PARASITOLOGY