Evaluation of the laser-induced thermotherapy treatment effect of breast cancer based on tissue viscoelastic properties

Chen, J. et al. (2018) Evaluation of the laser-induced thermotherapy treatment effect of breast cancer based on tissue viscoelastic properties. Journal of Engineering and Science in Medical Diagnostics and Therapy, 1(4), 041009. (doi:10.1115/1.4041502)

[img] Text
175032.pdf - Accepted Version
Restricted to Repository staff only until 17 October 2019.
Available under License Creative Commons Attribution.

1MB

Abstract

Photothermal therapy (PTT) has been emerging as an effective, minimally invasive approach to treat cancers. However, a method to quantitatively evaluate the treatment effect after laser-induced thermotherapy (LITT) is needed. In this study, we used 808 nm laser radiation with three different power densities to treat the breast cancer tissue from 4T1 cell lines in a mouse model. The viscoelastic properties of the treated cancer tissues were characterized by a two-term Prony series using a ramp-hold indentation method. We observed that instantaneous shear modulus G0 was significantly higher for the treated cancer tissues than that of the untreated tissue when treated with a power density of 1.5 W/cm2, but significantly lower with a power density of 2.5 W/cm2. The long-term shear modulus G∞ was also significantly higher for the cancer tissue at 1.5 W/cm2, compared to the untreated tissue. The treatment effects were verified by estimating the cell apoptosis rate using terminal deoxynucleotidyl transferase dUTP nick end labeling (TUNEL). Our results indicate that the viscoelastic properties of the tissue could potentially be used as biomarkers for evaluating the LITT treatment effect. In addition, we also observed a strain-independent behavior of the treated cancer tissue, which provided useful information for applying in vivo imaging method such as magnetic resonance elastography (MRE) for treatment evaluation based on biomechanical properties.

Item Type:Articles
Status:Published
Refereed:Yes
Glasgow Author(s) Enlighten ID:Aggarwal, Dr Ankush
Authors: Chen, J., Zhou, B., Qiu, S., Ma, S., Lee, C.-H., Aggarwal, A., Zeng, J., Gao, M., Feng, Y., Li, D., and Shan, H.
College/School:College of Science and Engineering > School of Engineering > Infrastructure and Environment
Journal Name:Journal of Engineering and Science in Medical Diagnostics and Therapy
Publisher:American Society of Mechanical Engineers
ISSN:2572-7958
Published Online:05 October 2018
Copyright Holders:Copyright © 2018 ASME
First Published:First published in Journal of Engineering and Science in Medical Diagnostics and Therapy 1(4):041009
Publisher Policy:Reproduced with the permission of the publisher

University Staff: Request a correction | Enlighten Editors: Update this record