Low dose rituximab is no less effective for nephrotic syndrome measured by 12-month outcome

Maxted, A. P., Dalrymple, R. A., Chisholm, D., McColl, J. , Tse, Y., Christian, M. T. and Reynolds, B. C. (2019) Low dose rituximab is no less effective for nephrotic syndrome measured by 12-month outcome. Pediatric Nephrology, 34(5), pp. 855-863. (doi: 10.1007/s00467-018-4172-3) (PMID:30564878) (PMCID:PMC6424916)

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Objective: Rituximab is an effective treatment for children with steroid dependent or frequently relapsing nephrotic syndrome. The optimum dosing schedule for rituximab has not been established. We hypothesized that a single low dose of 375 mg/m2 would have comparable outcomes to higher doses in reducing the frequency of relapse and time to B cell reconstitution. Methods: We conducted a multicenter retrospective observational cohort study of children with steroid-sensitive frequently relapsing nephrotic syndrome. Data were extracted from clinical records including the dates of diagnosis, treatment, relapses, the use of concomitant immunosuppression, and lymphocyte subset profiling. Patients treated earlier received variable doses of rituximab, although typically two doses of 750 mg/m2. Later, patients received the current regimen of a single dose of 375 mg/m2. The primary outcome was an absence of clinically confirmed relapse 12 months following rituximab administration. Secondary outcomes were median time to relapse, probability of being relapse-free at 6 and 24 months and time to reconstitution of CD19+ B cells. Results: Sixty patients received 143 courses of rituximab. Seven different dosing regimen strategies were used, ranging between 375 and 750 mg/m2 per dose, with administration of 1–4 doses. There was no significant difference in event-free survival at 12 months between dosing strategies. The median time to reconstitution of B cells was not significantly different between groups. Conclusions: Use of a single low-dose regimen of rituximab in the management of frequently relapsing nephrotic syndrome does not affect the probability of relapse at 12 months or time to B cell reconstitution compared to a conventional higher dose.

Item Type:Articles
Glasgow Author(s) Enlighten ID:McColl, Professor John and Reynolds, Dr Ben
Authors: Maxted, A. P., Dalrymple, R. A., Chisholm, D., McColl, J., Tse, Y., Christian, M. T., and Reynolds, B. C.
College/School:College of Medical Veterinary and Life Sciences > School of Medicine, Dentistry & Nursing
College of Science and Engineering > School of Mathematics and Statistics > Statistics
Journal Name:Pediatric Nephrology
ISSN (Online):1432-198X
Published Online:18 December 2018
Copyright Holders:Copyright © 2018 The Authors
First Published:First published in Pediatric Nephrology 34:855-863
Publisher Policy:Reproduced under a Creative Commons License

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